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Voriconazole

Name: Voriconazole
Brand: TargetMol
SKU: T0120
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0120Cas No. 137234-62-9

Alias UK-109496

Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 [CYP3A].

Voriconazole

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Purity: 99.91%

Catalog No. T0120Alias UK-109496Cas No. 137234-62-9

Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 [CYP3A].

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$30	In Stock	In Stock
25 mg	$50	In Stock	In Stock
50 mg	$71	In Stock	In Stock
100 mg	$112	In Stock	In Stock
200 mg	$160	In Stock	In Stock
500 mg	$266	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$34	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.91%

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Voriconazole (UK-109496) is a triazole antifungal agent that specifically inhibits STEROL 14-ALPHA-DEMETHYLASE and CYTOCHROME P-450 [CYP3A].
In vitro	Intraperitoneal administration of 5 mg/kg Voriconazole combined with 1.25 mg/kg Amphotericin B significantly reduces fungal counts in selected tissues of guinea pigs when compared to control groups. Furthermore, Voriconazole at 5 mg/kg, when combined with any dose of Caspofungin Acetate, decreases tissue fungal loads, specifically demonstrating a significant reduction in the number of positive cultures. In immunocompromised guinea pigs with pulmonary aspergillosis, Voriconazole effectively reduces pulmonary Aspergillus spp. counts, displaying superior results to those observed with Itraconazole.
In vivo	In vitro, Voriconazole exhibits greater or comparable antifungal activity against most tested molds than Itraconazole and Amphotericin B. Voriconazole effectively inhibits certain conditioned filamentous fungi and dimorphic fungi (molds), as well as yeast species. At concentrations of ≤1 μg/mL, Voriconazole can inhibit 95% of fungal strains.
Synonyms	UK-109496

Chemical Properties

Molecular Weight	349.31
Formula	C₁₆H₁₄F₃N₅O
Cas No.	137234-62-9
Smiles	CC(C1=NC=NC=C1F)C(O)(CN1C=NC=N1)C1=CC=C(F)C=C1F
Relative Density.	1.42 g/cm3

Storage & Solubility Information

Storage

store at low temperature | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: < 1 mg/mL (insoluble or slightly soluble)

Ethanol: 16 mg/mL (45.8 mM), Sonication is recommended.

DMSO: 247 mg/mL (707.11 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (14.31 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8628 mL	14.3139 mL	28.6279 mL	143.1393 mL
5 mM	0.5726 mL	2.8628 mL	5.7256 mL	28.6279 mL
10 mM	0.2863 mL	1.4314 mL	2.8628 mL	14.3139 mL
20 mM	0.1431 mL	0.7157 mL	1.4314 mL	7.1570 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0573 mL	0.2863 mL	0.5726 mL	2.8628 mL
100 mM	0.0286 mL	0.1431 mL	0.2863 mL	1.4314 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc