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Nimorazole

Name: Nimorazole
Brand: TargetMol
SKU: T2046
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T2046Cas No. 6506-37-2

Alias Nitrimidazine, Nimorazol, Naxogin, K-1900

Nimorazole (Nimorazol) is a nitroimidazole anti-infective.

Nimorazole

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Purity: 99.94%

Catalog No. T2046Alias Nitrimidazine, Nimorazol, Naxogin, K-1900Cas No. 6506-37-2

Nimorazole (Nimorazol) is a nitroimidazole anti-infective.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$32	In Stock	In Stock
50 mg	$43	In Stock	In Stock
100 mg	$56	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.94%

Color:White

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COA HNMR LCMS

Product Introduction

Nimorazole AI Summary

Nimorazole exhibits a diverse range of bioactivities and pharmacokinetic properties. It is effective in treating Entamoeba histolytica infections, with a minimum effective dose of 20.0 mg kg-1 per day for cecal infection in rats and 100.0 mg kg-1 per day for hepatic infection in hamsters. The compound shows moderate lipophilicity with a logP of 0.07 and demonstrates progressive biliary and renal excretion, indicating both hepatic and renal elimination pathways. Pharmacodynamically, it has multiple potencies across various targets, including: - Inhibiting HP1-beta chromodomain interactions (Potency 100000.0 nM), - Inhibiting Polymerase Iota (Potency 89125.1 nM), - Killing Giardia lamblia (Potency 325.6 nM and 5211.9 nM respectively), - Inhibiting Marburg Virus binding/entry (Potency 35481.3 nM), - Inhibiting ATXN expression (Potency 8.4 nM), - Acting as an agonist for gsp mutation (Potency 11220.2 nM), - Inhibiting human tyrosyl-DNA phosphodiesterase 1 (TDP1) (Potency 29092.9 nM), - Inhibiting the Ebola Virus entry, - Moderately inhibiting SARS-CoV-2 3CL-Pro protease by 19.88% at 20µM concentration. It also shows significant antimicrobial activity against Clostridium perfringens and Trichomonas vaginalis, with an MIC of 0.6 ug/mL and 12.5 ug/mL respectively. The compound has a therapeutic index of 40.0 for Trichomonas vaginalis in mice and low acute toxicity (LD50 1530.0 mg/kg in mice). However, it lacks significant activity against Staphylococcus aureus, Streptococcus pyogenes, and Mycoplasma gallisepticum. Additionally, Nimorazole has shown antiviral activity against SARS-CoV-2, inhibiting cytotoxicity in various cell lines, although with relatively low potency and high IC50 values (>20000.0 nM). It also inhibits human HDAC6 but with negligible percentages, indicating weak activity. Overall, while Nimorazole demonstrates some promising bioactivities, particularly against Entamoeba histolytica and certain antimicrobial pathogens, its effectiveness against SARS-CoV-2 and human HDAC6, among other targets, is limited..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Nimorazole (Nimorazol) is a nitroimidazole anti-infective.
Synonyms	Nitrimidazine, Nimorazol, Naxogin, K-1900

Chemical Properties

Molecular Weight	226.23
Formula	C₉H₁₄N₄O₃
Cas No.	6506-37-2
Smiles	[O-][N+](=O)c1cncn1CCN1CCOCC1
Relative Density.	1.42g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (265.22 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (8.84 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	4.4203 mL	22.1014 mL	44.2028 mL	221.0140 mL
5 mM	0.8841 mL	4.4203 mL	8.8406 mL	44.2028 mL
10 mM	0.4420 mL	2.2101 mL	4.4203 mL	22.1014 mL
20 mM	0.2210 mL	1.1051 mL	2.2101 mL	11.0507 mL
50 mM	0.0884 mL	0.4420 mL	0.8841 mL	4.4203 mL
100 mM	0.0442 mL	0.2210 mL	0.4420 mL	2.2101 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc