Galectin-1 Protein, Mouse, Recombinant

Name: Galectin-1 Protein, Mouse, Recombinant
Brand: TargetMol
SKU: TMPY-02102
Rating: 4.5 (1 reviews)

(Synonyms: lectin, galactoside-binding, soluble, 1, Lect14, L-14.5, L14, galectin-1, Galbp, Gal-1, AA410090) Copy Product Info

Synonyms: lectin, galactoside-binding, soluble, 1, Lect14, L-14.5, L14, galectin-1, Galbp, Gal-1, AA410090

Catalog No. TMPY-02102 Copy Product Info

Galectin-1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P16045.

Pack Size	Price	USA Stock	Global Stock
5 µg	$84	7-10 days	7-10 days
10 µg	$135	7-10 days	7-10 days
20 µg	$215	7-10 days	7-10 days
50 µg	$388	7-10 days	7-10 days
100 µg	$621	7-10 days	7-10 days
200 µg	Inquiry	7-10 days	7-10 days
500 µg	Inquiry	7-10 days	7-10 days
1 mg	Inquiry	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Measured by its ability to agglutinate human red blood cells. The ED50 for this effect is typically 6-60 μg/ml.
Description	Galectin-1 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P16045.
Species	Mouse
Expression System	E. coli
Tag	Tag Free
Accession Number	P16045
Construction	A DNA sequence encoding the mouse Lgals1 (P16045) (Met 1-Glu 135) was expressed and purified. Predicted N terminal: Met 1
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	Please contact us for more information.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	lectin, galactoside-binding, soluble, 1, Lect14, L-14.5, L14, galectin-1, Galbp, Gal-1, AA410090
Research Background	Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for beta-galactosides and by significant sequence similarity in the carbohydrate-binding site. It is a homodimer with a subunit molecular mass of 14.5 kDa, which contains six cysteine residues per subunit. The cysteine residues should be in a free state to maintain a molecular structure that is capable of showing lectin activity. This endogenous lectin widely expressed at sites of inflammation and tumor growth has been postulated as an attractive immunosuppressive agent to restore immune cell tolerance and homeostasis in autoimmune and inflammatory settings. On the other hand, galectin-1 contributes to different steps of tumor progression including cell adhesion, migration, and tumor-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation, and allergies as well as host-pathogen interactions.

Chemical Properties

Molecular Weight

15 kDa (predicted); 15 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.