D1R antagonist 2

Name: D1R antagonist 2
Brand: TargetMol
SKU: T212961
Rating: 4.5 (1 reviews)

Catalog No. T212961 Copy Product Info

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D1R antagonist 2 (Compound 13a) is a blood-brain barrier-permeable D1R antagonist, with IC50 values of 35.6 nM for cAMP-based D1R and 70 nM for β-arrestin-based D1R. It effectively inhibits D1R-mediated cAMP and β-arrestin recruitment and is applicable in studies of neurodegenerative and neuropsychiatric disorders, such as schizophrenia, Parkinson's disease, and Alzheimer's disease.

D1R antagonist 2

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Catalog No. T212961

D1R antagonist 2

Pack Size	Price	USA Stock	Global Stock	Quantity
10 mg	Inquiry	Inquiry	Inquiry
50 mg	Inquiry	Inquiry	Inquiry

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	D1R antagonist 2 (Compound 13a) is a blood-brain barrier-permeable D1R antagonist, with IC50 values of 35.6 nM for cAMP-based D1R and 70 nM for β-arrestin-based D1R. It effectively inhibits D1R-mediated cAMP and β-arrestin recruitment and is applicable in studies of neurodegenerative and neuropsychiatric disorders, such as schizophrenia, Parkinson's disease, and Alzheimer's disease.
Targets&IC50	D1 Receptor:35.6 (cAM nM

Chemical Properties

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc