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Anti-CLU Monoclonal Antibody-Biotin
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Catalog No. TMAZ-0178B
Alias Testosterone-repressed prostate message 2, Sulfated glycoprotein 2, NA1/NA2, Ku70-binding protein 1, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, Clusterin, Apolipoprotein J, Aging-associated gene 4 protein
Anti-CLU Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-Biotin can be used in ELISA,FCM,IF.
Anti-CLU Monoclonal Antibody-Biotin
Anti-CLU Monoclonal Antibody-Biotin
😃Good
Catalog No. TMAZ-0178BAlias Testosterone-repressed prostate message 2, Sulfated glycoprotein 2, NA1/NA2, Ku70-binding protein 1, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, Clusterin, Apolipoprotein J, Aging-associated gene 4 protein
Anti-CLU Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-Biotin can be used in ELISA,FCM,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μg | $196 | 12 days | 12 days | |
| 50 μg | $236 | 12 days | 12 days | |
| 100 μg | $330 | 12 days | 12 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
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Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CLU Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting CLU. Anti-CLU Monoclonal Antibody-Biotin can be used in ELISA,FCM,IF. |
| Synonyms | Testosterone-repressed prostate message 2, Sulfated glycoprotein 2, NA1/NA2, Ku70-binding protein 1, Complement-associated protein SP-40,40, Complement cytolysis inhibitor, Clusterin, Apolipoprotein J, Aging-associated gene 4 protein |
| Ig Type | Rabbit monoclonal IgG |
| Reactivity | Human |
| Verified Activity | Flow cytometry analysis of CLU overexpressed 355F cells with TMAZ-0178B, followed by goat anti-rabbit IgG-ABflo 647 (red line). The isotype control is rabbit IgG (black line). |
| Application | |
| Recommended Dose | 0.1-0.2 μg/10E6 cells for FCM; 1 ng/μl for ELISA |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Single-pass type I membrane |
| Construction | This antibody was produced from a rabbit immunized with purified, recombinant human extracellular domain of CLU protein. |
| Purification | Protein A Affinity Purified |
| Appearance | Liquid |
| Formulation | 0.22 μm filtered solution in PBS. |
| Purity | > 95% as determined by SDS-PAGE. |
| Research Background | Functions as extracellular chaperone that prevents aggregation of non native proteins (PubMed: 11123922, PubMed: 19535339). Prevents stress-induced aggregation of blood plasma proteins (PubMed: 11123922, PubMed: 12176985, PubMed: 17260971, PubMed: 19996109). Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro) (PubMed: 12047389, PubMed: 17407782, PubMed: 17412999). Does not require ATP (PubMed: 11123922). Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70 (PubMed: 11123922). Does not refold proteins by itself (PubMed: 11123922). Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation (PubMed: 21505792). Protects cells against apoptosis and against cytolysis by complement (PubMed: 2780565). Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed: 20068069). Promotes proteasomal degradation of COMMD1 and IKBKB (PubMed: 20068069). Modulates NF-kappa-B transcriptional activity (PubMed: 12882985). A mitochondrial form suppresses BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis (PubMed: 16113678, PubMed: 17689225). Plays a role in the regulation of cell proliferation (PubMed: 19137541). An intracellular form suppresses stress-induced apoptosis by stabilizing mitochondrial membrane integrity through interaction with HSPA5 (PubMed: 22689054). Secreted form does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Secreted form act as an important modulator during neuronal differentiation through interaction with STMN3 (By similarity). Plays a role in the clearance of immune complexes that arise during cell injury (By similarity)|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity|Does not affect caspase or BAX-mediated intrinsic apoptosis and TNF-induced NF-kappa-B-activity (PubMed: 24073260). Promotes cell death through interaction with BCL2L1 that releases and activates BAX (PubMed: 21567405) |
| Conjucates | Biotin |
| Others Formats | Unconjugated |
| Antibody Types Available | 2 |
| Immunogen | CLU |
| Antigen Species | Human |
| Gene ID | |
| Uniprot ID | |
| Biology Area | Drug Target |
| Molecular Weight | 150 kDa |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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