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Hepln-13

Name: Hepln-13
Brand: TargetMol
SKU: T25492
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25492Cas No. 64369-13-7

Alias Hepln13, Hepln 13

Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.

Hepln-13

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Purity: 97.67%

Catalog No. T25492Alias Hepln13, Hepln 13Cas No. 64369-13-7

Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$32	In Stock	In Stock
2 mg	$46	In Stock	In Stock
5 mg	$77	In Stock	In Stock
10 mg	$128	In Stock	In Stock
25 mg	$257	In Stock	In Stock
50 mg	$383	In Stock	In Stock
100 mg	$533	In Stock	In Stock
200 mg	$737	-	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.67%

Appearance:Solid

Color:Yellow

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.
Targets&IC50	Hepsin:0.33 μM
In vitro	Hepln-13 (10 μM; 2 hours; 293 cells) inhibits cleavage[1].
In vivo	HepIn-13 displays dose-dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes in LPB-Tag/PB-Hepsin mice and blocks prostate cancer metastasis in this animal model.
Synonyms	Hepln13, Hepln 13

Chemical Properties

Molecular Weight	325.2
Formula	C₁₇H₁₃BrN₂
Cas No.	64369-13-7
Smiles	Brc1ccc(cc1)C1Nc2cccc3cccc(N1)c23
Relative Density.	1.444g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (184.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.15 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0750 mL	15.3752 mL	30.7503 mL	153.7515 mL
5 mM	0.6150 mL	3.0750 mL	6.1501 mL	30.7503 mL
10 mM	0.3075 mL	1.5375 mL	3.0750 mL	15.3752 mL
20 mM	0.1538 mL	0.7688 mL	1.5375 mL	7.6876 mL
50 mM	0.0615 mL	0.3075 mL	0.6150 mL	3.0750 mL
100 mM	0.0308 mL	0.1538 mL	0.3075 mL	1.5375 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc