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Hepln-13

🥰Excellent
Catalog No. T25492Cas No. 64369-13-7
Alias Hepln13, Hepln 13

Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.

Hepln-13

Hepln-13

🥰Excellent
Purity: 97.67%
Catalog No. T25492Alias Hepln13, Hepln 13Cas No. 64369-13-7
Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$32In StockIn Stock
2 mg$46In StockIn Stock
5 mg$77In StockIn Stock
10 mg$128In StockIn Stock
25 mg$257In StockIn Stock
50 mg$383In StockIn Stock
100 mg$533In StockIn Stock
200 mg$737-In Stock
1 mL x 10 mM (in DMSO)$88In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:97.67%
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Product Introduction

Bioactivity
Description
Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.
Targets&IC50
Hepsin:0.33 μM
In vitro
Hepln-13 (10 μM; 2 hours; 293 cells) inhibits cleavage[1].
In vivo
HepIn-13 displays dose-dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes in LPB-Tag/PB-Hepsin mice and blocks prostate cancer metastasis in this animal model.
SynonymsHepln13, Hepln 13
Chemical Properties
Molecular Weight325.2
FormulaC17H13BrN2
Cas No.64369-13-7
SmilesBrc1ccc(cc1)C1Nc2cccc3cccc(N1)c23
Relative Density.1.444g/cm3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 60 mg/mL (184.50 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (6.15 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0750 mL15.3752 mL30.7503 mL153.7515 mL
5 mM0.6150 mL3.0750 mL6.1501 mL30.7503 mL
10 mM0.3075 mL1.5375 mL3.0750 mL15.3752 mL
20 mM0.1538 mL0.7688 mL1.5375 mL7.6876 mL
50 mM0.0615 mL0.3075 mL0.6150 mL3.0750 mL
100 mM0.0308 mL0.1538 mL0.3075 mL1.5375 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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μL
2 Enter the in vivo formulation:
% DMSO
%
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% Saline/PBS/ddH2O

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

prostatepotentphenotypesoverexpression-relevantorallynon-toxicInhibitorinhibitHGFRhepsinHepln-13cMet/HGFRc-MetcMetcancer
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