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Hepln-13

Name: Hepln-13
Brand: TargetMol
SKU: T25492
Price: 32 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25492Cas No. 64369-13-7

Alias Hepln13, Hepln 13

Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.

Hepln-13

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Purity: 97.67%

Catalog No. T25492Alias Hepln13, Hepln 13Cas No. 64369-13-7

Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.

Pack Size	Price	Availability
1 mg	$32	In Stock
2 mg	$46	In Stock
5 mg	$77	In Stock
10 mg	$128	In Stock
25 mg	$257	In Stock
50 mg	$383	In Stock
100 mg	$533	In Stock
200 mg	$737	In Stock
1 mL x 10 mM (in DMSO)	$88	In Stock

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Batch Information

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Purity:97.67%

Resource Download

COA LCMS HPLC HNMR

Product Introduction

Bioactivity

Description	Hepln-13 is a hepsin inhibitor that acts by hindering prostate cancer bone metastasis.
Targets&IC50	Hepsin:0.33 μM
In vitro	Hepln-13 (10 μM; 2 hours; 293 cells) inhibits cleavage[1].
In vivo	HepIn-13 displays dose-dependent inhibition of Hepsin overexpression-relevant prostate cancer phenotypes in LPB-Tag/PB-Hepsin mice and blocks prostate cancer metastasis in this animal model.
Synonyms	Hepln13, Hepln 13

Chemical Properties

Molecular Weight	325.2
Formula	C₁₇H₁₃BrN₂
Cas No.	64369-13-7
Smiles	Brc1ccc(cc1)C1Nc2cccc3cccc(N1)c23
Relative Density.	1.444g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (184.50 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.0750 mL	15.3752 mL	30.7503 mL	153.7515 mL
5 mM	0.6150 mL	3.0750 mL	6.1501 mL	30.7503 mL
10 mM	0.3075 mL	1.5375 mL	3.0750 mL	15.3752 mL
20 mM	0.1538 mL	0.7688 mL	1.5375 mL	7.6876 mL
50 mM	0.0615 mL	0.3075 mL	0.6150 mL	3.0750 mL
100 mM	0.0308 mL	0.1538 mL	0.3075 mL	1.5375 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc