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α-Synuclein inhibitor 8

Catalog No. T72314 CAS 2883627-64-1

α-Synuclein inhibitor 8 effectively impedes α-Synuclein aggregation and disaggregation with an IC50 of 2.5 µM, demonstrating substantial reduction in neuronal inclusion formation, which contributes to reparative effects in damaged neurons and symptomatic improvement in Parkinson’s disease (PD)-like models. The compound also exhibits high antioxidant activity and low cytotoxicity [1].

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α-Synuclein inhibitor 8 Chemical Structure

α-Synuclein inhibitor 8, CAS 2883627-64-1

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

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Description	α-Synuclein inhibitor 8 effectively impedes α-Synuclein aggregation and disaggregation with an IC50 of 2.5 µM, demonstrating substantial reduction in neuronal inclusion formation, which contributes to reparative effects in damaged neurons and symptomatic improvement in Parkinson’s disease (PD)-like models. The compound also exhibits high antioxidant activity and low cytotoxicity [1].
In vitro	α-Synuclein inhibitor 8 (Compound 2ee) inhibits α-Synuclein aggregation in a dose-dependent manner (0-100 µM; 0-96 h) [1]. At a concentration of 100 µM and exposure time of 48 h, it disassembles mature fibrils into soluble proteins and a small amount of short insoluble fibers [1]. Additionally, α-Synuclein inhibitor 8 increases the rate of reactive oxygen species scavenging dose-dependently (1-1000 µM; 0.5 h or 24 h). It exhibits low cytotoxicity in H4 and SH-SY5Y cells, with cell viability exceeding 80% [1]. At 10 µM for 38 h, α-Synuclein inhibitor 8 shows inhibitory effects on the formation of α-Synuclein aggregation and inclusion bodies within H4 cells [1].
In vivo	Compound 2ee (α-Synuclein inhibitor 8), administered at a single dose of 0.9 μg/μL via intravenous injection, significantly ameliorated symptoms such as reduced grip strength, limb rigidity, and impaired balance in a Parkinson's disease (PD) C57 mouse model. Furthermore, α-Synuclein inhibitor 8 demonstrated a neuroprotective effect on the caudate putamen (CPu) and substantia nigra pars reticulata (SNr) within the brains of these Parkinson's disease C57 mouse models [1].

Molecular Weight	432.43
Formula	C24H20N2O6
CAS No.	2883627-64-1

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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α-Synuclein inhibitor 8 2883627-64-1 inhibitor inhibit

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