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Protein deglycase DJ-1 against-1
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Catalog No. T62174Cas No. 724737-74-0
Protein deglycase DJ-1 against-1 (compound 23) is able to penetrate the blood-brain barrier (BBB) and bind to the C106 region of the DJ-1 protein, preventing DJ-1 over-oxidation to enhance cellular resistance to oxidative stress, thereby restoring neuronal cellular observed in a neurotoxin MPTP-induced model of Parkinson's disease (PD) death and motor deficits.
Protein deglycase DJ-1 against-1
😃Good
Purity: 97.23%
Catalog No. T62174Cas No. 724737-74-0
Protein deglycase DJ-1 against-1 (compound 23) is able to penetrate the blood-brain barrier (BBB) and bind to the C106 region of the DJ-1 protein, preventing DJ-1 over-oxidation to enhance cellular resistance to oxidative stress, thereby restoring neuronal cellular observed in a neurotoxin MPTP-induced model of Parkinson's disease (PD) death and motor deficits.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $40 | In Stock | In Stock | |
| 25 mg | $61 | In Stock | In Stock | |
| 50 mg | $87 | In Stock | - | |
| 100 mg | $125 | 7-10 days | 7-10 days | |
| 1 mL x 10 mM (in DMSO) | $39 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:97.23%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Protein deglycase DJ-1 against-1 (compound 23) is able to penetrate the blood-brain barrier (BBB) and bind to the C106 region of the DJ-1 protein, preventing DJ-1 over-oxidation to enhance cellular resistance to oxidative stress, thereby restoring neuronal cellular observed in a neurotoxin MPTP-induced model of Parkinson's disease (PD) death and motor deficits. |
| In vivo | In the MPTP-induced Parkinson’s mouse model, intraperitoneal injection of compound-23 (1 mg/kg for 4 days) improved motor deficits, protected dopaminergic neurons, and restored dopamine levels; however, these effects were absent in Protein deglycase DJ-1 against-1 knockout mice, indicating Protein deglycase DJ-1 against-1-dependent activity[1]. |
| Molecular Weight | 417.46 |
| Formula | C24H23N3O4 |
| Cas No. | 724737-74-0 |
| Smiles | O=C(NC=1C=CC(=CC1)C=2N=C3C(=CC=CN3C2)C)C4=CC(OC)=C(OC)C(OC)=C4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 16 mg/mL (38.33 mM), adjust pH to 7 with NaOH. | |||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.79 mM), Sonication is recommended. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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