p38 gamma/MAPK12 Protein, Human, Recombinant

Name: p38 gamma/MAPK12 Protein, Human, Recombinant
Brand: TargetMol
SKU: TMPY-04430
Rating: 4.5 (1 reviews)

(Synonyms: SAPK-3, SAPK3, PRKM12, P38γ, P38GAMMA, P38 γ/MAPK12, mitogen-activated protein kinase 12, MAPK12, ERK-6, ERK6, ERK3) Copy Product Info

Synonyms: SAPK-3, SAPK3, PRKM12, P38γ, P38GAMMA, P38 γ/MAPK12, mitogen-activated protein kinase 12, MAPK12, ERK-6, ERK6, ERK3

Catalog No. TMPY-04430 Copy Product Info

p38 gamma/MAPK12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.1 kDa and the accession number is P53778.

Pack Size	Price	USA Stock	Global Stock
10 µg	$152	7-10 days	7-10 days
20 µg	$248	7-10 days	7-10 days
50 µg	$577	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	Kinase activity untested
Description	p38 gamma/MAPK12 Protein, Human, Recombinant is expressed in Baculovirus insect cells. The predicted molecular weight is 42.1 kDa and the accession number is P53778.
Species	Human
Expression System	Baculovirus Insect Cells
Tag	Tag Free
Accession Number	P53778
Construction	A DNA sequence encoding the human MAPK12 (P53778) (Met1-Leu367) was fused with two additional amino acids (Gly & Pro) at the N-terminus. Predicted N terminal: Gly
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Supplied as sterile 20 mM Tris, 500 mM NaCl, 10% glycerol, pH 8.0.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	SAPK-3, SAPK3, PRKM12, P38γ, P38GAMMA, P38 γ/MAPK12, mitogen-activated protein kinase 12, MAPK12, ERK-6, ERK6, ERK3
Research Background	ERK3, also known as MAPK12 and p38-gamma, belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. ERK3 is highly expressed in skeletal muscle and heart. ERK3 is a serine/threonine kinase that acts as an essential component of the MAP kinase signal transduction pathway. MAPK12 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors such as ELK1 and ATF2. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 2 to 3 substrates each. MAPK12 is required for the normal kinetochore localization of PLK1, prevents chromosomal instability, and supports mitotic cell viability. MAPK12-signaling is also positively regulating the expansion of transient amplifying myogenic precursor cells during muscle growth and regeneration.

Chemical Properties

Molecular Weight

42.1 kDa (predicted); 43 kDa (reducing conditions)

Storage & Solubility Information

Shipping	Proteins are shipped with blue ice.
Storage	It is recommended to store the product under sterile conditions at -20°C to -80°C. Samples are stable for up to 12 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.