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Betahistine dihydrochloride

Name: Betahistine dihydrochloride
Brand: TargetMol
SKU: T0246
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0246Cas No. 5579-84-0

Alias PT-9, Betahistine 2HCl

Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator.

Betahistine dihydrochloride

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Purity: 99.65%

Catalog No. T0246Alias PT-9, Betahistine 2HClCas No. 5579-84-0

Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Purity:99.65%

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Betahistine dihydrochloride (Betahistine 2HCl) is a histamine analog and H1 receptor agonist that serves as a vasodilator.
Targets&IC50	H3 receptor:1.9 μM
In vitro	In mice, Betahistine (ED50=2 mg/kg) elevates t-MeHA levels in a dose-dependent manner. In patients with Ménière's disease, Betahistine (16 mg, twice daily for 3 months) significantly alleviates vertigo. Additionally, Betahistine (50 mg/kg) induces an upregulation of histidine decarboxylase mRNA in the nodose ganglion of the cat brain.
In vivo	In CHO(H3R) cells treated with 3 μM of, Betahistine progressively increased cAMP formation, peaking at 10 nM. Furthermore, in CHO(H3R) cells, Betahistine progressively reduced A23187-induced [3H]arachidonic acid release (EC50=0.1 nM), with the greatest effect observed at 30 nM.
Synonyms	PT-9, Betahistine 2HCl

Chemical Properties

Molecular Weight	209.12
Formula	C₈H₁₄Cl₂N₂
Cas No.	5579-84-0
Smiles	Cl.Cl.CNCCC1=NC=CC=C1
Relative Density.	0.967 g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (239.1 mM), Sonication is recommended.

H2O: 35 mg/mL (167.37 mM), Sonication is recommended.

Ethanol: 1 mg/mL (4.78 mM), Sonication is recommended.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	4.7819 mL	23.9097 mL	47.8194 mL	239.0972 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
5 mM	0.9564 mL	4.7819 mL	9.5639 mL	47.8194 mL
10 mM	0.4782 mL	2.3910 mL	4.7819 mL	23.9097 mL
20 mM	0.2391 mL	1.1955 mL	2.3910 mL	11.9549 mL
50 mM	0.0956 mL	0.4782 mL	0.9564 mL	4.7819 mL
100 mM	0.0478 mL	0.2391 mL	0.4782 mL	2.3910 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc