Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ZZL-7 is a fast-onset antidepressant agent. ZZL-7 disrupts the interaction between the neuronal nitric oxide synthase (nNOS) and serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the blood-brain barrier readily. ZZL-7 has research value in major depressive disorder (MDD).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 47.00 | |
10 mg | In stock | $ 72.00 | |
25 mg | In stock | $ 163.00 | |
50 mg | In stock | $ 247.00 | |
100 mg | In stock | $ 372.00 | |
200 mg | In stock | $ 549.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 50.00 |
Description | ZZL-7 is a fast-onset antidepressant agent. ZZL-7 disrupts the interaction between the neuronal nitric oxide synthase (nNOS) and serotonin transporter (SERT) in the dorsal raphe nucleus (DRN). ZZL-7 can easily cross the blood-brain barrier readily. ZZL-7 has research value in major depressive disorder (MDD). |
In vitro | In 293T cells transfected with nNOS and SERT, ZZL-7 (1.0 μM; 2 h) significantly decreases the SERT-nNOS complex level[1]. |
In vivo | ZZL-7 (10 mg/kg; intraperitoneal administration) reverses chronic unpredictable mild stress (CMS)-induced depressions behaviors 2 hours after treatment. ZZL-7 (10, 20, and 40 mg/kg; Intragastric administration; once) produces antidepressant-like behaviors dose dependently 2 hours after treatment. ZZL-7 (10 mg/kg, intraperitoneally) causes significantly increases firing frequency of serotonergic neurons 2 hours after treatment in vivo electrophysiology in SERT-Cre mice. In wild-type mice, ZZL-7 reduces immobility time[1]. |
Molecular Weight | 244.29 |
Formula | C11H20N2O4 |
CAS No. | 99141-91-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 12 mg/mL (49.12 mM)
You can also refer to dose conversion for different animals. More
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ZZL-7 99141-91-0 Neuroscience Serotonin Transporter ZZL 7 ZZL7 inhibitor inhibit