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heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens]
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Catalog No. TP2256
Heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens] is a peptide with the sequence H2N-Phe-Thr-Val-Asp-Arg- Pro-Phe-Leu-Phe-Leu-Ile-Tyr-Glu-His-Arg-OH, MW=1953.25.
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heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens]
Copy Product Info😃Good
Catalog No. TP2256
Heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens] is a peptide with the sequence H2N-Phe-Thr-Val-Asp-Arg- Pro-Phe-Leu-Phe-Leu-Ile-Tyr-Glu-His-Arg-OH, MW=1953.25.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $50 | Inquiry | Inquiry | |
| 5 mg | $143 | Inquiry | Inquiry | |
| 10 mg | $235 | Inquiry | Inquiry | |
| 25 mg | $329 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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| Description | Heparin cofactor II precursor (SERPIND1) fragment [Homo sapiens] is a peptide with the sequence H2N-Phe-Thr-Val-Asp-Arg- Pro-Phe-Leu-Phe-Leu-Ile-Tyr-Glu-His-Arg-OH, MW=1953.25. |
| In vitro | Heparin cofactor II(HCII), a protein encoded by the SERPIND1 gene, is a coagulation factor that inhibits IIa and is a cofactor for heparin and dermatan sulfate. The product encoded by this gene is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. The gene contains five exons and four introns. This protein shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. Heparin Cofactor II deficiency can lead to increased thrombin generation and a hypercoagulable state [1][2]. |
| Molecular Weight | 1953.25 |
| Formula | C95H137N23O22 |
| Smiles | N[C@@]([H])(C/C1=C/C=CC=C1)C(=O)N[C@]([H])(C(=O)N[C@]([H])(C(=O)N[C@@]([H])(CC(O)=O)C(=O)N[C@@]([H])(CCCNC(N)=N)C(=O)N2CCC[C@@]2([H])C(=O)N[C@]([H])(C/C3=C/C=CC=C3)C(=O)N[C@@]([H])(CC(C)(C)[H])C(=O)N[C@]([H])(C/C4=C/C=CC=C4)C(=O)N[C@]([H])(CC(C)(C)[H])C(=O)N[C@]([H])(C(=O)N[C@@]([H])(C/C5=C/C=C(/O)C=C5)C(=O)N[C@@]([H])(CCC(O)=O)C(=O)N[C@@]([H])(C/C6=C/N=CN6)C(=O)N[C@@]([H])(CCCNC(N)=N)C(O)=O)[C@](C)([H])CC)C(C)(C)[H])[C@@](C)(O)[H] |
| Relative Density. | no data available |
| Sequence | H-Phe-Thr-Val-Asp-Arg-Pro-D-Phe-Leu-D-Phe-D-Leu-Ile-Tyr-Glu-His-Arg-OH |
| Sequence Short | FTVDRPFLFLIYEHR |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
| Solubility Information | DMSO: ≥65.1 mg/mL, Sonication is recommended. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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