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2'-Deoxyguanosine

Name: 2'-Deoxyguanosine
Brand: TargetMol
SKU: T22218
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T22218Cas No. 961-07-9

Alias Guanine deoxyriboside, Deoxyguanosine

2'-Deoxyguanosine (Guanine deoxyriboside) is a purine nucleoside that is recognized by members of the 2'-dG-II family.2'-Deoxyguanosine has been associated with aging, mutation, and carcinogenesis, and is oxidized by molecular oxygen.

2'-Deoxyguanosine

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Purity: 99.86%

Catalog No. T22218Alias Guanine deoxyriboside, DeoxyguanosineCas No. 961-07-9

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
500 mg	$39	In Stock	-
1 mL x 10 mM (in DMSO)	$43	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.86%

Appearance:Solid

Color:White

Resource Download

COA HNMR HPLC

Product Introduction

2'-Deoxyguanosine AI Summary

2'-Deoxyguanosine exhibits a wide range of bioactivities, including potent antiviral effects against herpes simplex virus-1 (HSV-1), herpes simplex virus-2 (HSV-2), varicella zoster virus, and human cytomegalovirus. It shows antiproliferative effects on human leukemia cells and inhibits cellular replication in specific cancer cell lines such as Friend erythroleukemia and HGPRT- HL-60 cells with ID50 values of 0.29 mM and 0.49 mM, respectively. The compound demonstrates inhibitory activity against HSV-1 thymidine kinase with an ID50 value of 300.0 µM and displays selective inhibition of HIV replication in MT-4 cells with an ED50 of 158.0 µM, showing no cytotoxicity at a dose of CD50 > 500.0 µM (Selectivity Index = 3.1). Furthermore, 2'-Deoxyguanosine affects the activity of deoxycytidine kinase and deoxyguanosine kinase from Staphylococcus aureus. It modulates lipid storage in Drosophila S3 cells, inhibits Tau fibril formation, impacts lipid storage, inhibits chronic active B-cell receptor signaling, induces genotoxicity in HEK293T cells, and induces synthetic lethality in tumor cells producing 2HG. The compound also inhibits TDP1 activity and shows activity against Vaccinia Orthopoxvirus. Additionally, it significantly inhibits sodium fluorescein uptake in OATP1B1 and OATP1B3 transfected CHO cells. In cytotoxicity assays, 2'-Deoxyguanosine shows relatively low toxicity in various cell lines, with an IC50 greater than 250,000 nM. It also exhibits an activity level of 65% in human erythrocyte purine nucleoside phosphorylase assays. Overall, 2'-Deoxyguanosine demonstrates diverse biological activities, making it a compound of interest for further research in antiviral therapeutics, cancer treatment, and other bioactive applications..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	2'-Deoxyguanosine (Guanine deoxyriboside) is a purine nucleoside that is recognized by members of the 2'-dG-II family.2'-Deoxyguanosine has been associated with aging, mutation, and carcinogenesis, and is oxidized by molecular oxygen.
Synonyms	Guanine deoxyriboside, Deoxyguanosine

Chemical Properties

Molecular Weight	267.24
Formula	C₁₀H₁₃N₅O₄
Cas No.	961-07-9
Smiles	O=C1C2=C(N(C=N2)[C@@H]3O[C@H](CO)[C@@H](O)C3)NC(N)=N1
Relative Density.	2.08g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 100 mg/mL (374.2 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (14.97 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7420 mL	18.7098 mL	37.4195 mL	187.0977 mL
5 mM	0.7484 mL	3.7420 mL	7.4839 mL	37.4195 mL
10 mM	0.3742 mL	1.8710 mL	3.7420 mL	18.7098 mL
20 mM	0.1871 mL	0.9355 mL	1.8710 mL	9.3549 mL
50 mM	0.0748 mL	0.3742 mL	0.7484 mL	3.7420 mL
100 mM	0.0374 mL	0.1871 mL	0.3742 mL	1.8710 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc