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PF-06726304

Name: PF-06726304
Brand: TargetMol
SKU: T12428L
Price: 33 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T12428LCas No. 1616287-82-1

PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively).

PF-06726304

🥰Excellent

Purity: 99.51%

Catalog No. T12428LCas No. 1616287-82-1

PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively).

Pack Size	Price	Availability
1 mg	$33	In Stock
2 mg	$46	In Stock
5 mg	$74	In Stock
10 mg	$127	In Stock
25 mg	$293	In Stock
50 mg	$531	In Stock
100 mg	$768	In Stock
1 mL x 10 mM (in DMSO)	$81	In Stock

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Purity:99.51%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	PF-06726304 shows robust antitumor growth activity. PF-06726304 is an effective and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 (Kis: 0.7 and 3.0 nM, respectively).
Targets&IC50	EZH2 (WT):0.7 nM （ki）, EZH2 (Y641N):3.0 nM （ki）
In vitro	PF-06726304 suppresses the proliferation of Karpas-422 cells that harbor wild-type EZH2 (IC50: 25 nM). PF-06726304 suppresses H3K27me3 in Karpas-422 (IC50: 15 nM) [1].
In vivo	In a subcutaneous Karpas-422 xenograft model, PF-06726304 (200 and 300 mg/kg; BID for 20 days) suppresses tumor growth and causes robust modulation of downstream biomarkers[1].

Chemical Properties

Molecular Weight	446.33
Formula	C₂₂H₂₁Cl₂N₃O₃
Cas No.	1616287-82-1
Smiles	Cc1noc(C)c1-c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl
Relative Density.	1.333 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 45 mg/mL (100.82 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2405 mL	11.2025 mL	22.4049 mL	112.0247 mL
5 mM	0.4481 mL	2.2405 mL	4.4810 mL	22.4049 mL
10 mM	0.2240 mL	1.1202 mL	2.2405 mL	11.2025 mL
20 mM	0.1120 mL	0.5601 mL	1.1202 mL	5.6012 mL
50 mM	0.0448 mL	0.2240 mL	0.4481 mL	2.2405 mL
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1202 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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