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Pomalidomide-PEG3-C2-NH2 hydrochloride

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Catalog No. T40105Cas No. 2446474-09-3
Alias Pomalidomide-PEG3-C2-NH2 hydrochloride, E3ligaseLigand-LinkerConjugates30hydrochloride, Cereblon Ligand-Linker Conjugates 5 hydrochloride

Pomalidomide-PEG3-C2-NH2 hydrochloride, also known as Cereblon Ligand-Linker Conjugate 5, is a chemically synthesized E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand based on Pomalidomide and a linker commonly employed in PROTAC technology.

Pomalidomide-PEG3-C2-NH2 hydrochloride
Other Forms of Pomalidomide-PEG3-C2-NH2 hydrochloride:

Pomalidomide-PEG3-C2-NH2 hydrochloride

😃Good
Catalog No. T40105Alias Pomalidomide-PEG3-C2-NH2 hydrochloride, E3ligaseLigand-LinkerConjugates30hydrochloride, Cereblon Ligand-Linker Conjugates 5 hydrochlorideCas No. 2446474-09-3
Pomalidomide-PEG3-C2-NH2 hydrochloride, also known as Cereblon Ligand-Linker Conjugate 5, is a chemically synthesized E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand based on Pomalidomide and a linker commonly employed in PROTAC technology.
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25 mg$75835 days35 days
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.
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Product Introduction

Bioactivity
Description
Pomalidomide-PEG3-C2-NH2 hydrochloride, also known as Cereblon Ligand-Linker Conjugate 5, is a chemically synthesized E3 ligase ligand-linker conjugate. This compound incorporates a cereblon ligand based on Pomalidomide and a linker commonly employed in PROTAC technology.
In vitro
PROTACs consist of two ligands linked together: one binds to an E3 ubiquitin ligase, and the other targets the protein. They utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins [2].
SynonymsPomalidomide-PEG3-C2-NH2 hydrochloride, E3ligaseLigand-LinkerConjugates30hydrochloride, Cereblon Ligand-Linker Conjugates 5 hydrochloride
Chemical Properties
Molecular Weight484.93
FormulaC21H29ClN4O7
Cas No.2446474-09-3
SmilesCl.NCCOCCOCCOCCNc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Pomalidomide-PEG3-C2-NH2 HydrochloridePomalidomide-PEG-3-C2-NH2 hydrochloridePomalidomidePEG3C2NH2 hydrochloridePomalidomide PEG3 C2 NH2 hydrochlorideCereblon Ligand-Linker Conjugates 5 Hydrochloride
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