Naproxen etemesil

Name: Naproxen etemesil
Brand: TargetMol
SKU: T16272
Rating: 4.5 (1 reviews)

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Catalog No. T16272Cas No. 385800-16-8

Alias MX 1094, LT-NS 001

Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.

Naproxen etemesil

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Catalog No. T16272Alias MX 1094, LT-NS 001Cas No. 385800-16-8

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$854	6-8 weeks	6-8 weeks
50 mg	$1,110	6-8 weeks	6-8 weeks
100 mg	$1,610	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$259	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Product Introduction

Bioactivity

Description	Naproxen is a COX-1 and COX-2 inhibitor (IC50s: 8.72 and 5.15 μM, respectively in cell assay). Naproxen etemesil is a lipophilic and non-acidic prodrug of naproxen. It is hydrolyzed to pharmacologically active Naproxen once absorbed.
Targets&IC50	COX-2:5.15 μM, COX-1:8.72 μM
In vitro	Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is an approximately equipotent inhibitor of COX-1 and COX-2 in intact cells (IC50s: 2.2 μg/mL and 1.3 μg/mL, respectively)[1].
In vivo	Naproxen is shown to inhibit the time-courses of pain, fever, and PGE2 with similar potencies (IC50=27, 40, 13 μM). Naproxen exerts an anti-inflammatory and antifibrotic effect in the mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation [2][3].
Synonyms	MX 1094, LT-NS 001

Chemical Properties

Molecular Weight	336.4
Formula	C₁₇H₂₀O₅S
Cas No.	385800-16-8
Relative Density.	1.238 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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