Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 64.00 | |
5 mg | In stock | $ 197.00 | |
10 mg | In stock | $ 293.00 | |
25 mg | In stock | Inquiry | |
50 mg | In stock | Inquiry |
Description | Filibuvir (PF-00868554) is a selective and noncovalent inhibitor of HCV NS5B RNA-dependent RNA polymerase. Filibuvir inhibits genotype 1a and 1b replicons with EC50s of 59 nM. |
In vitro | In Huh7.5 cells, Filibuvir (0.01-10000 nM; 48 h) dose-dependently inhibits the WT 1b replicon with EC50s of ∼70 nM. Filibuvir decreases primer extension from PE46 with an IC50 of 73 nM, but has no obvious effect on de novo-initiated RNA synthesis with IC50 of 5 μM[2]. |
Synonyms | PF-00868554 |
Molecular Weight | 503.64 |
Formula | C29H37N5O3 |
CAS No. | 877130-28-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 9mg/mL (17.9mM)
You can also refer to dose conversion for different animals. More
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Filibuvir 877130-28-4 Cell Cycle/Checkpoint DNA Damage/DNA Repair Microbiology/Virology Proteases/Proteasome HCV Protease DNA/RNA Synthesis PF-00868554 PF 00868554 PF00868554 inhibitor inhibit