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Anti-Phospho-PKC gamma (Thr514) Polyclonal Antibody
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Catalog No. TMAB-11155
Anti-Phospho-PKC gamma (Thr514) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC gamma (Thr514). Anti-Phospho-PKC gamma (Thr514) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Phospho-PKC gamma (Thr514) Polyclonal Antibody
Anti-Phospho-PKC gamma (Thr514) Polyclonal Antibody
😃Good
Catalog No. TMAB-11155
Anti-Phospho-PKC gamma (Thr514) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC gamma (Thr514). Anti-Phospho-PKC gamma (Thr514) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $220 | 7-10 days | 7-10 days | |
| 100 μL | $371 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-PKC gamma (Thr514) Polyclonal Antibody is a Rabbit antibody targeting Phospho-PKC gamma (Thr514). Anti-Phospho-PKC gamma (Thr514) Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Chicken,Pig,Cow,Horse,Rabbit) |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm.Cell membrane. |
| Tissue Specificity | Expressed in Purkinje cells of the cerebellar cortex. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14). [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated Synthesised phosphopeptide: human PKC gamma around the phosphorylation site of Thr514 |
| Antigen Species | Human |
| Gene Name | PRKCG |
| Gene ID | |
| Protein Name | Protein kinase C gamma type |
| Uniprot ID | |
| Function | This is a calcium-activated, phospholipid-dependent, serine- and threonine-specific enzyme.
PKC is activated by diacylglycerol which in turn phosphorylates a range of cellular proteins. PKC also serves as the receptor for phorbol esters, a class of tumor promoters. |
| Molecular Weight | Theoretical: 78 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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