VU6000918

Name: VU6000918
Brand: TargetMol
SKU: T39543
Rating: 4.5 (1 reviews)

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Catalog No. T39543Cas No. 2101737-32-8

VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.

VU6000918

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Catalog No. T39543Cas No. 2101737-32-8

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Product Introduction

Bioactivity

Description	VU6000918 is a positive allosteric modulator that targets the muscarinic acetylcholine receptor subtype M4. It exhibits a half maximal effective concentration (EC50) of 19 nM for the human M4 receptor.
Targets&IC50	M4 (human):19 nM (EC50)
In vitro	VU6000918 significantly reverses AHL by 18% at a minimal oral dosage of 0.03 mg/kg and achieves peak reversal of 74% with a 3 mg/kg dosage, yielding an in vivo plasma EC50 of 74 nM (0.66 nM unbound) according to terminal concentrations observed in study animals 1.5 hours after administering compound 17j[1].

Chemical Properties

Molecular Weight	389.42
Formula	C₁₈H₁₇F₂N₅OS
Cas No.	2101737-32-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

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