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Vopratelimab
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Catalog No. T77434Cas No. 2039148-04-2
Alias JTX 2011
Vopratelimab (JTX-2011) is a selective humanized immunoglobulin G1-kappa monoclonal antibody and a potent ICOS agonist with high affinity for inducible T cell co-stimulating factors (ICOS), showing affinities of 0.93 nM for hICOS, 3.7 nM for rat ICOS, and 0.64 nM for mICOS. It exhibits anti-tumor immune effects and can improve metastatic non-small cell lung cancer.
Vopratelimab
Vopratelimab
😃Good
Catalog No. T77434Alias JTX 2011Cas No. 2039148-04-2
Vopratelimab (JTX-2011) is a selective humanized immunoglobulin G1-kappa monoclonal antibody and a potent ICOS agonist with high affinity for inducible T cell co-stimulating factors (ICOS), showing affinities of 0.93 nM for hICOS, 3.7 nM for rat ICOS, and 0.64 nM for mICOS. It exhibits anti-tumor immune effects and can improve metastatic non-small cell lung cancer.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $413 | - | In Stock | |
| 5 mg | $1,070 | - | In Stock | |
| 10 mg | $1,650 | - | In Stock | |
| 25 mg | $2,460 | - | In Stock | |
| 50 mg | $3,320 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.34% (SEC-HPLC)
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| Description | Vopratelimab (JTX-2011) is a selective humanized immunoglobulin G1-kappa monoclonal antibody and a potent ICOS agonist with high affinity for inducible T cell co-stimulating factors (ICOS), showing affinities of 0.93 nM for hICOS, 3.7 nM for rat ICOS, and 0.64 nM for mICOS. It exhibits anti-tumor immune effects and can improve metastatic non-small cell lung cancer. |
| In vitro | Vopratelimab (JTX-2011; 0.001-10 μg/mL; 3 days; CD4 T cells) activates primary human T cells, inducing the secretion of IFNγ, IL-17a, IL-10, IL-9, GM-CSF, TNFα, and IL-21[1]. |
| In vivo | Vopratelimab (JTX-2011; 0.25-0.3 mg/kg; i.p.; twice weekly for 2 weeks) induces tumor regression in the Sa1/N syngeneic mouse tumor model[1]. |
| Synonyms | JTX 2011 |
| Reactivity | Human |
| Application | Functional assay |
| Antibody Type | Monoclonal |
| Endotoxin | <1.0 EU/mg |
| Conjucates | Unconjugated |
| Gene ID | |
| Uniprot ID | |
| Target | ICOS/CD278 |
| Molecular Weight | 145.74 kDa |
| Cas No. | 2039148-04-2 |
| Isotype | Human IgG1 kappa |
| Recommended Isotype Control |
| Storage | store at low temperature | -20°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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