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Vopratelimab (JTX-2011) is a selective humanized immunoglobulin G1-kappa monoclonal antibody that is a potent ICOS agonist. Vopratelimab has a high affinity for inducible T cell CO stimulating factors (ICOS), with an affinity of 0.93 nM for hICOS, 3.7 nM for rat ICOS, and 0.64 nM for mICOS. Vopratelimab has an anti-tumor immune effect and can be used to improve metastatic non-small cell lung cancer.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 455.00 | |
5 mg | In stock | $ 1,180.00 | |
10 mg | In stock | $ 1,980.00 | |
25 mg | In stock | $ 2,970.00 | |
50 mg | In stock | $ 3,970.00 | |
100 mg | In stock | Inquiry |
Description | Vopratelimab (JTX-2011) is a selective humanized immunoglobulin G1-kappa monoclonal antibody that is a potent ICOS agonist. Vopratelimab has a high affinity for inducible T cell CO stimulating factors (ICOS), with an affinity of 0.93 nM for hICOS, 3.7 nM for rat ICOS, and 0.64 nM for mICOS. Vopratelimab has an anti-tumor immune effect and can be used to improve metastatic non-small cell lung cancer. |
In vitro | Vopratelimab (JTX-2011; 0.001-10 μg/mL; 3 days; CD4 T cells) exhibits the activity to activate primary human T cells, driving the secretion of IFNγ, IL-17a, IL-10, IL-9, GM-CSF, TNFα, and IL-21[1]. |
In vivo | Vopratelimab (JTX-2011; 0.25-0.3 mg/kg; i.p.; twice weekly for 2 weeks) promotes tumor regression in the Sa1/N syngeneic mouse tumor model[1]. |
Synonyms | JTX 2011 |
Molecular Weight | N/A |
CAS No. | 2039148-04-2 |
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store at -80°C
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Vopratelimab 2039148-04-2 Others JTX2011 JTX 2011 JTX-2011 inhibitor inhibit