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SB-1436
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Catalog No. T87366Cas No. 2925298-08-2
SB-1436 is a Cholinesterase (ChE) inhibitor that inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and recombinant human acetylcholinesterase (rHuAChE) with IC50 values of 0.176, 0.37, and 0.08 μM, respectively. It inhibits AChE and BChE in a non-competitive manner with Ki values of 0.046 and 0.115 μM, respectively. Additionally, SB-1436 significantly prevents the self-aggregation of Aβ and can be used for neurological disease research [1].
SB-1436
😃Good
Catalog No. T87366Cas No. 2925298-08-2
SB-1436 is a Cholinesterase (ChE) inhibitor that inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and recombinant human acetylcholinesterase (rHuAChE) with IC50 values of 0.176, 0.37, and 0.08 μM, respectively. It inhibits AChE and BChE in a non-competitive manner with Ki values of 0.046 and 0.115 μM, respectively. Additionally, SB-1436 significantly prevents the self-aggregation of Aβ and can be used for neurological disease research [1].
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | 10-14 weeks | 10-14 weeks | |
| 50 mg | Inquiry | 10-14 weeks | 10-14 weeks |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Chemical Properties
| Description | SB-1436 is a Cholinesterase (ChE) inhibitor that inhibits acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and recombinant human acetylcholinesterase (rHuAChE) with IC50 values of 0.176, 0.37, and 0.08 μM, respectively. It inhibits AChE and BChE in a non-competitive manner with Ki values of 0.046 and 0.115 μM, respectively. Additionally, SB-1436 significantly prevents the self-aggregation of Aβ and can be used for neurological disease research [1]. |
| Targets&IC50 | eqBCHE:0.115 μM (Ki), Ee AChE:0.046 μM (Ki), Ee AChE:0.176 μM, eqBCHE:0.37 μM |
| In vitro | SB-1436 (Compound 7av) at a concentration of 1 μM for 20 minutes inhibits AChE, BChE, and rHuAChE, with IC50 values of 0.176, 0.37, and 0.08 μM, respectively [1]. This compound, administered at concentrations ranging from 0.78 to 100 μM for 48 hours, decreases the viability of J774A.1 cells and primary astrocytes, with a GI50 of approximately 6.25 μM in both cell lines [1]. |
| Molecular Weight | 405.89 |
| Formula | C25H21ClFNO |
| Cas No. | 2925298-08-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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