CLK3 Protein, Human, Recombinant (Active, GST)

Catalog No. TMPC-00185 Copy Product Info

CLK3 Protein, Human, Recombinant (Active, GST) is expressed in Baculovirus-Insect Cells. The accession number is P49761.

CLK3 Protein, Human, Recombinant (Active, GST)

Catalog No. TMPC-00185

Copy Product Info

CLK3 Protein, Human, Recombinant (Active, GST) is expressed in Baculovirus-Insect Cells. The accession number is P49761.

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10 μg	$1,390	Inquiry	Inquiry

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Biological Activity	The specific activity of CLK3 was determined to be 28.9 nmol /min/mg by ADP-Glo kinase assay.
Description	CLK3 Protein, Human, Recombinant (Active, GST) is expressed in Baculovirus-Insect Cells. The accession number is P49761.
Species	Human
Expression System	Baculovirus-Insect Cells
Tag	N-GST
Accession Number	P49761
Synonyms	Dual specificity protein kinase CLK3,CLK3,CDC-like kinase 3
Construction	Recombinant full length human CLK3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Protein Purity	>80% as determined by SDS-PAGE.
Molecular Weight	~86 kDa
Formulation	Supplied as sterile 50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	Enzymes are highly recommended to be shipped at frozen temperature with dry ice. Shipment made at ambient temperature may seriously affect the activity of the ordered products.
Research Background	Dual specificity protein kinase CLK3, also known as CDC-like kinase 3, and CLK3, is a member of CMGC Ser/Thr protein kinase family and Lammer subfamily. Mammalian CLK is the prototype for a family of dual specificity kinases (termed Lammer kinases) that have been conserved in evolution. CLK family members have shown to interact with, and phosphorylate, serine- and arginine-rich (SR) proteins of the spliceosomal complex, which is a part of the regulatory mechanism that enables the SR proteins to control RNA splicing. The three members of the CLK family of kinases (CLK1, CLK2, and CLK3) have been shown to undergo conserved alternative splicing to generate catalytically active and inactive isoforms. The human CLK2 and CLK3 are found within the nucleus and display dual-specificity kinase activity. The truncated isoforms, hCLK2(T) and hCLK3(T), colocalize with SR proteins in nuclear speckles. CLK3 may play a role in the development and progression of azoospermia.