Pepsinogen C/PGC Protein, Human, Recombinant (His)

Name: Pepsinogen C/PGC Protein, Human, Recombinant (His)
Brand: TargetMol
SKU: TMPY-01731
Rating: 4.5 (1 reviews)

(Synonyms: progastricsin (pepsinogen C), PGII, PEPC) Copy Product Info

Synonyms: progastricsin (pepsinogen C), PGII, PEPC

Catalog No. TMPY-01731 Copy Product Info

Pepsinogen C/PGC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is P20142-1.

Pack Size	Price	USA Stock	Global Stock
5 µg	$129	7-10 days	7-10 days
10 µg	$215	7-10 days	7-10 days
20 µg	$413	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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User Guide of Recombinant Proteins

Product Information

Bioactivity

Bioactivity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	Pepsinogen C/PGC Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42 kDa and the accession number is P20142-1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His
Accession Number	P20142-1
Construction	A DNA sequence encoding the human PGC (NP_002621.1) (Met 1-Ala 388) was fused with a polyhistidine tag at the C-terminus. Predicted N terminal: Ala 17
Protein Purity	> 95 % as determined by SDS-PAGE
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing 50 mM Tris, 150 mM NaCl, pH 7.5. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Synonyms	progastricsin (pepsinogen C), PGII, PEPC
Research Background	Pepsinogen C, also known as PGC, is an aspartic proteinase that belongs to the peptidase family A1. Pepsinogen C is synthesized in the gastric mucosa as inactive precursors, known as zymogens. Pepsinogen C contains a prosegment that serves to stabilize the inactive form and prevent entry of the substrate to the active site. At low PH conditions, Pepsinogen C undergoes conversion into active enzyme. Pepsinogen C has been found expressed in all regions of the stomach mucosa and also in the proximal duodenal mucosa. In stomach cancer tissues and cancer cell lines, the expressions of the pepsinogen genes were decreased or lost, in good accordance with their pepsinogen productions. No gross structural changes of the pepsinogen genes were observed in these cancers, but the methylation patterns of the pepsinogen genes were found to be altered in different ways in different cancers. Serum levels of Pepsinogen C are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis.

Chemical Properties

Molecular Weight

42 kDa (predicted); 42 kDa (reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

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Keywords

progastricsinpepsinogen C

Related Tags: Pepsinogen C/PGC Protein, Human, Recombinant (His) chemical structure | Pepsinogen C/PGC Protein, Human, Recombinant (His) molecular weight