Shopping Cart
Remove All
  • TargetMol
    Your shopping cart is currently empty

Cannabinoid Receptor

Cannabinoid receptors are of a class of cell membrane receptors in the G protein-coupled receptor superfamily. As is typical of G protein-coupled receptors, the cannabinoid receptors contain seven transmembrane spanning domains. Cannabinoid receptors are activated by three major groups of ligands: endocannabinoids, produced by the mammillary body;[citation needed] plant cannabinoids (such as cannabidiol, produced by the cannabis plant); and synthetic cannabinoids (such as HU-210). All of the endocannabinoids and phytocannabinoids (plant based cannabinoids) are lipophilic, such as fat soluble compounds.

Anandamide
(5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide
T1404694421-68-8
Anandamide ((5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide), an immune modulator, acts via not only cannabinoid receptors (CB1 and CB2) but also other targets (e.g., GPR18/GPR55) in the central nervous system.
  • $30
In Stock
Size
QTY
GW 405833
L-768242
T7705180002-83-9
GW 405833 (L-768242) is an agonist of cannabinoid-2 (CB(2)) receptor-selective
  • $31
In Stock
Size
QTY
NESS 0327
T22114494844-07-4In house
NESS 0327 is a high selectivity antagonist of the cannabinoid CB1 receptor. NESS 0327 is more than 60,000-fold selective for the CB1 receptor.
  • $48
In Stock
Size
QTY
Pregnenolone monosulfate
3β-Hydroxy-5-pregnen-20-one monosulfate
T125361247-64-9
Pregnenolone monosulfate (3β-Hydroxy-5-pregnen-20-one monosulfate) is a potent nootropic steroid that positively regulates NMDA recordings and is utilized in the study of neuroticism and depression.
  • $46
In Stock
Size
QTY
KLS-13019
KLS13019, KLS 13019
T324021801243-39-9
KLS-13019 is a highly effective and orally active GPR55 receptor antagonist, a cannabidiol (CBD)-derived neuroprotective agent that can reverse chemotherapy-induced peripheral neuropathy (CIPN) and is suitable for studying hepatic encephalopathy (HE).
  • $497
In Stock
Size
QTY
AM251
T1915183232-66-8
AM251 is a effective CB1 receptor antagonist (IC50/Ki: 8 /7.49 nM) that displays 306-fold selectivity over CB2 receptors; also effective GPR55 agonist (EC50: 39 nM).
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited
Olorinab
APD 371
T143021268881-20-4
Olorinab (APD 371) (APD 371) is a highly potent, selective and fully efficacious cannabinoid receptor type 2 (CB2) agonist. With an EC50 of 6.2 nM for hCB2.
  • $51
In Stock
Size
QTY
O-1602
O1602, O 1602
T23097317321-41-8
O-1602 is a novel GPR55 agonist, an atypical cannabinoid associated with the central nervous system and obesity, and is a candidate compound for the treatment of cystitis.O-1602 promotes hepatic steatosis through GPR55 and PI3 kinase / Akt / SREBP-1c signalling in mice.O-1602 induces, in a GPR3-independent manner, in Hep55B cells with elevated intracellular calcium.
  • $39
In Stock
Size
QTY
Tetrahydromagnolol
TN226820601-85-8
Tetrahydromagnolol can activate cannabinoid (CB) receptors.
  • $50
In Stock
Size
QTY
AM1241
T6755444912-48-5
AM-1241 is a selective cannabinoid CB2 receptor agonist with Ki of 3.4 nM, exhibits 82-fold selectivity over CB1 receptor.
  • $32
In Stock
Size
QTY
Linoleoyl Ethanolamide
T842568171-52-8
Linoleoyl Ethanolamide is an endocannabinoid agent. It acts by binding to TRPV1 increasing ERK phosphorylation and AP-1 dependent transcription in CB-receptor in an independent manner.
  • $30
In Stock
Size
QTY
CB 65
T41230913534-05-1In house
CB 65 is a high affinity and selective CB2 receptor agonist with Ki values of 3.3 and > 1000 nM for CB2 and CB1 receptors respectively.
  • $35
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Otenabant hydrochloride
Otenabant (CP-945598) HCl, Otenabant, CP 945598 Hydrochloride
T1796686347-12-6
Otenabant hydrochloride (Otenabant) (CP-945598) is a competitive, high affinity, selective antagonist of the CB1 receptor (Ki: 0.7 nM).
  • $39
In Stock
Size
QTY
(±)-Ibipinabant
SLV319, (±)-SLV319, (±)-BMS6462
T4654362519-49-1
(±)-Ibipinabant ((±)-SLV319) has been utilized in clinical trials for the treatment of obesity and type 2 diabetes.
  • $43
In Stock
Size
QTY
Rimonabant
SR141716
T1519L168273-06-1
Rimonabant (SR141716) is an inverse agonist for the cannabinoid receptor CB1. It is an anorectic anti-obesity drug produced and marketed by Sanofi-Aventis. Its main avenue of effect is a reduction in appetite. Rimonabant is the first selective CB1 receptor blocker to be approved for use anywhere in the world. Rimonabant is approved in 38 countries including the E.U., Mexico, and Brazil. It was rejected for approval for use in the United States.
  • $42
In Stock
Size
QTY
TargetMol | Citations Cited
Pregnenolone monosulfate sodium
3β-Hydroxy-5-pregnen-20-one monosulfate sodium
T165741852-38-6
Pregnenolone monosulfate sodium salt is the sodium salt form of Pregnenolone monosulfate.Pregnenolone monosulfate is an endogenous neurosteroid, enhances NMDA receptor-mediated synaptic activity and intracellular Ca²⁺ concentrations, activates CREB phosphorylation, activates TRPM3 channels, and may inhibit GABA A receptors.
  • $29
In Stock
Size
QTY
JHU 75528
JHU-75528, JHU75528
T77634947696-17-5In house
JHU 75528 (JHU-75528) is a novel PET tracer with inhibitory effects on CB that can be used to study the cannabinoid system in schizophrenic patients.
  • $195
In Stock
Size
QTY
GW 833972A
T643941092502-33-4In house
GW 833972A is a selective CB2 receptor agonist that inhibits induced neural depolarization and citric acid-induced cough in an animal model.
  • $178
In Stock
Size
QTY
PSB-SB-487
T89751399049-81-0
PSB-SB-487 is antagonist of GPR55.
  • $32
In Stock
Size
QTY
Nonabine
T2818716985-03-8In house
Nonabine is a compound with strong antiemetic properties that can be used to prevent nausea and vomiting associated with cancer chemotherapy.
  • $142
In Stock
Size
QTY
ML-193
CID 1261822
T22103713121-80-3
ML-193 (CID 1261822) is a potent and selective GPR55 antagonist (IC50: 221 nM) with over 27-fold selectivity for GPR55 over GPR35, CB1, and CB2. It can ameliorate motor and sensorimotor deficits in Parkinson's disease (PD) rats.
  • $39
In Stock
Size
QTY
6-Iodopravadoline
AM630
T14204164178-33-0
6-Iodopravadoline (AM630) is an antagonist of CB2 (Ki: 31.2 nM). And it shows 165-fold selectivity more than CB1 receptors.
  • $34
In Stock
Size
QTY
TargetMol | Citations Cited
β-Caryophyllene
(−)-β-caryophyllene, (−)-trans-Caryophyllene, (-)-(E)-Caryophyllene
T911487-44-5
β-Caryophyllene ((-)-(E)-Caryophyllene) acts as an CB2 receptor agonist.
  • $30
In Stock
Size
QTY
TargetMol | Citations Cited