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STF-083010

Name: STF-083010
Brand: TargetMol
SKU: T6681
Price: 47 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T6681Cas No. 307543-71-1

Alias STF083010

STF-083010 is a selective inhibitor of the IRE1α endonuclease.

STF-083010

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Purity: 99.45%

Catalog No. T6681Alias STF083010Cas No. 307543-71-1

STF-083010 is a selective inhibitor of the IRE1α endonuclease.

Pack Size	Price	Availability
5 mg	$47	In Stock
10 mg	$73	In Stock
25 mg	$123	In Stock
50 mg	$215	In Stock
100 mg	$387	In Stock
200 mg	$585	In Stock
500 mg	$853	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock

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Batch Information

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Purity:99.45%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	STF-083010 is a selective inhibitor of the IRE1α endonuclease.
In vitro	WaC3 cells respond to treatments with STF-083010 with gradually decreased growth. In MEC1 and MEC2 cells, STF-083010 produces 20% growth inhibition in 48 hours cultures. In MM.1R MM, MM.1S, and RPMI 8226 cell lines, STF-083010 displays cytostatic and cytotoxic activity in a dose and time-dependent manner. In Eμ-TCL1 CLL cells, STF-083010 displays about 70% growth inhibition after 3 days culture. In SU8686, Panc0403, and MiaPaCa2 cell lines, STF-083010 blocks IRE1α's endonuclease and inhibits XBP1 splicing activity without affecting its kinase activity.
In vivo	STF-083010 (i.p., 30 mg/kg) signi?cantly inhibits the growth of the tumor in human multiple myeloma (MM) xenografts model.
Kinase Assay	Autophosphorylation activity is measured by adding of 32P-γ ATP. Endonuclease activity is measured by the adding of radiolabeled HAC1 508-nt RNA substrate synthesized in vitro using α32P-UTP. Mix STF083010 with recombinant hIRE1 protein, radiolabeled HAC1 508 nt RNA, and appropriate buffers to incubate. Kinase activity is quantitated by polyacrylamide gel electrophoresis. RNAsecleavage products are quantitated by 32P-γATP or 32P-UTP autoradiography.
Cell Research	3×10E3 (Panc0403, Panc1005, BxPc3, and MiaPaCa2) cell lines are seeded in 96-well plates overnight, and STF-083010(~50 μM) treatment for 48 hours started the next day.
Animal Research	NOD/SCID/IL2Rγ null mice were injected intraperitoneally of STF-083010(30 mg/kg) dissolved in 16% chremophor.
Synonyms	STF083010

Chemical Properties

Molecular Weight	317.38
Formula	C₁₅H₁₁NO₃S₂
Cas No.	307543-71-1
Smiles	O=C1C=Cc2ccccc2\C1=C\NS(=O)(=O)c1cccs1
Relative Density.	1.40 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 40 mg/mL (126.03 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1508 mL	15.7540 mL	31.5080 mL	157.5399 mL
5 mM	0.6302 mL	3.1508 mL	6.3016 mL	31.5080 mL
10 mM	0.3151 mL	1.5754 mL	3.1508 mL	15.7540 mL
20 mM	0.1575 mL	0.7877 mL	1.5754 mL	7.8770 mL
50 mM	0.0630 mL	0.3151 mL	0.6302 mL	3.1508 mL
100 mM	0.0315 mL	0.1575 mL	0.3151 mL	1.5754 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc