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Anti-4-1BB/CD137/TNFRSF9 Antibody (1B772)
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Catalog No. TMAY-00148
Alias tumor necrosis factor receptor superfamily, member 9, Ly63, ILA, CDw137, Cd137, AI325004, AA408498, A930040I11Rik, 4-1BB
Anti-4-1BB/CD137/TNFRSF9 Antibody (1B772) is a Rabbit antibody targeting 4-1BB/CD137/TNFRSF9. Anti-4-1BB/CD137/TNFRSF9 Antibody (1B772) can be used in FCM.
Anti-4-1BB/CD137/TNFRSF9 Antibody (1B772)
Anti-4-1BB/CD137/TNFRSF9 Antibody (1B772)
😃Good
Catalog No. TMAY-00148Alias tumor necrosis factor receptor superfamily, member 9, Ly63, ILA, CDw137, Cd137, AI325004, AA408498, A930040I11Rik, 4-1BB
Anti-4-1BB/CD137/TNFRSF9 Antibody (1B772) is a Rabbit antibody targeting 4-1BB/CD137/TNFRSF9. Anti-4-1BB/CD137/TNFRSF9 Antibody (1B772) can be used in FCM.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $269 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: FCM Reactivity: Human |
| Alias | tumor necrosis factor receptor superfamily, member 9, Ly63, ILA, CDw137, Cd137, AI325004, AA408498, A930040I11Rik, 4-1BB |
| Ig Type | Rabbit IgG |
| Clone | 1B772 |
| Reactivity | Human |
| Verified Activity | Flow cytometric analysis of Human CD137 expression on PHA-activated human whole blood lymphocytes. Cells were stained with purified anti-Human CD137, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes. |
| Application | FCM |
| Recommended Dose | FCM: 1:25-1:100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human CD137 (rh CD137; TMPY-01743; NP_001552.2; Met1-Gln186). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+and CD8+T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. Soluble forms of CD137 (sCD137) are generated by differential splicing. sCD137 can bind to CD137 ligand to antagonize the costimulatory activities of the membrane-bound CD137 and reduce T cell proliferation and IL-2 secretion.Cancer ImmunotherapyCo-stimulatory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: AntibodiesImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy |
| Conjucates | Unconjugated |
| Others Formats | APC/FITC/PE |
| Antibody Types Available | 4 |
| Immunogen | Recombinant Protein: Human CD137 Protein (TMPY-01743) |
| Antigen Species | Human |
| Biology Area | Cancer Drug Targets |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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