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Polyethylene glycol 12-hydroxystearate

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Catalog No. T19562Cas No. 61909-81-7
Alias Solutol HS-15

Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.

Polyethylene glycol 12-hydroxystearate

Polyethylene glycol 12-hydroxystearate

😃Good
Purity: 98%
Catalog No. T19562Alias Solutol HS-15Cas No. 61909-81-7
Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
5 g$30-In Stock
10 g$41-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98%
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COA HNMR

Product Introduction

Bioactivity
Description
Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.
In vitro
Polyethylene glycol 12-hydroxystearate promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Polyethylene glycol 12-hydroxystearate, relative to the respective control, at 4°C. Polyethylene glycol 12-hydroxystearate treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control).
SynonymsSolutol HS-15
Chemical Properties
Molecular Weight361.567
FormulaC20H43NO4
Cas No.61909-81-7
SmilesN.CCCCCCC(O)CCCCCCCCCCC(=O)OCCO
Relative Density.no data available
ColorWhite
AppearanceViscous
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 262.00 mg/mL (724.62 mM)
Ethanol: 100.00 mg/mL (276.57 mM), Sonication is recommended.
H2O: 25.00 mg/mL (69.14 mM), Sonication is recommended.
Solution Preparation Table
H2O/Ethanol/DMSO
1mg5mg10mg50mg
1 mM2.7657 mL13.8287 mL27.6574 mL138.2870 mL
5 mM0.5531 mL2.7657 mL5.5315 mL27.6574 mL
10 mM0.2766 mL1.3829 mL2.7657 mL13.8287 mL
20 mM0.1383 mL0.6914 mL1.3829 mL6.9143 mL
50 mM0.0553 mL0.2766 mL0.5531 mL2.7657 mL
Ethanol/DMSO
1mg5mg10mg50mg
100 mM0.0277 mL0.1383 mL0.2766 mL1.3829 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

SolutolPolyethylene glycol 12-hydroxystearatePolyethylene glycol 12hydroxystearatePolyethylene glycol 12 hydroxystearateInhibitorinhibitHS-15
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