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Polyethylene glycol 12-hydroxystearate

Name: Polyethylene glycol 12-hydroxystearate
Brand: TargetMol
SKU: T19562
Price: 30 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19562Cas No. 61909-81-7

Alias Solutol HS-15

Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.

Polyethylene glycol 12-hydroxystearate

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Purity: 98%

Catalog No. T19562Alias Solutol HS-15Cas No. 61909-81-7

Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
5 g	$30	-	In Stock
10 g	$41	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:98%

Color:White

Resource Download

COA HNMR

Product Introduction

Bioactivity

Description	Polyethylene glycol 12-hydroxystearate (Solutol HS-15) is a permeability enhancer.
In vitro	Polyethylene glycol 12-hydroxystearate promotes the apical-to-basolateral translocation of a model protein (insulin) across Calu-3 monolayers when applied at 37°C. Furthermore there is no statistically significant increase in insulin permeability in the presence of Polyethylene glycol 12-hydroxystearate, relative to the respective control, at 4°C. Polyethylene glycol 12-hydroxystearate treated cells show a statistically significant increase in permeability towards lower molecular weight permeants (5 to 22 kDa) and an absence of a statistically significant increase in permeability of proteins with larger molecular weight, namely albumin and IgG (P>0.05 relative to control).
Synonyms	Solutol HS-15

Chemical Properties

Molecular Weight	361.567
Formula	C₂₀H₄₃NO₄
Cas No.	61909-81-7
Smiles	N.CCCCCCC(O)CCCCCCCCCCC(=O)OCCO
Relative Density.	no data available

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year

Solubility Information

DMSO: 262.00 mg/mL (724.62 mM)

Ethanol: 100.00 mg/mL (276.57 mM), Sonication is recommended.

H2O: 25.00 mg/mL (69.14 mM), Sonication is recommended.

Solution Preparation Table

H2O/Ethanol/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7657 mL	13.8287 mL	27.6574 mL	138.2870 mL
5 mM	0.5531 mL	2.7657 mL	5.5315 mL	27.6574 mL
10 mM	0.2766 mL	1.3829 mL	2.7657 mL	13.8287 mL
20 mM	0.1383 mL	0.6914 mL	1.3829 mL	6.9143 mL
50 mM	0.0553 mL	0.2766 mL	0.5531 mL	2.7657 mL

Ethanol/DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0277 mL	0.1383 mL	0.2766 mL	1.3829 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

SolutolPolyethylene glycol 12-hydroxystearatePolyethylene glycol 12hydroxystearatePolyethylene glycol 12 hydroxystearateInhibitorinhibitHS-15

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