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Anti-IRE1 Antibody (6O834)
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Catalog No. TMAY-02143
Alias IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1
Anti-IRE1 Antibody (6O834) is a Rabbit antibody targeting IRE1. Anti-IRE1 Antibody (6O834) can be used in ELISA.
Anti-IRE1 Antibody (6O834)
Anti-IRE1 Antibody (6O834)
😃Good
Catalog No. TMAY-02143Alias IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1
Anti-IRE1 Antibody (6O834) is a Rabbit antibody targeting IRE1. Anti-IRE1 Antibody (6O834) can be used in ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 100 μL | $268 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: ELISA Reactivity: Human |
| Alias | IRE1P, IRE1a, IRE1, hIRE1p, endoplasmic reticulum to nucleus signaling 1 |
| Ig Type | Rabbit IgG |
| Clone | 6O834 |
| Reactivity | Human |
| Application | ELISA |
| Recommended Dose | ELISA: 1:5000-1:10000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Human ERN1 / IRE1 (rh ERN1 / IRE1; TMPY-04413; O75460-1; Pro465-Leu977). |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Endoplasmic reticulum stress and hypoxia are necessary components of malignant tumors growth and suppression of ERN1 (from endoplasmic reticulum to nuclei-1) signalling pathway, which is linked to the apoptosis and cell death processes, significantly decreases proliferative processes. An enhanced expression of TP53 gene in ERN1 knockdown glioma cells correlates with the decreased level of ubiquitin ligase MDM2 and increased expression level of USP7 which deubiquitinates TP53 and MDM2 and induces TP53-dependent cell growth repression and apoptosis. Thus, the expression of genes encoding TP53 and related to TP53 factors depends upon the endoplasmic reticulum stress signaling as well as on hypoxia, and correlates with suppression of glioma growth under ERN1 knockdown. The dependence of insulin-like growth binding proteins as well as IGF2BP3 and HTRA1 gene expressions in U87 glioma cells on ERN1 signaling enzyme function and hypoxia, indicating its participation in the regulation of metabolic and proliferative processes via IGF/INS receptors, because endoplasmic reticulum stress is an important component of tumor growth and metabolic diseases. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein: Human ERN1 / IRE1 protein (TMPY-04413) |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . 
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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