G Protein-Coupled Receptors, GPCRs

CC chemokine receptor (CCR) 8 (previously called CKR-L1 or TER1 and designated CD198), which is expressed on Th2 cells and eosinophils, has been implicated in allergic diseases. CCR8 may regulate monocyte chemotaxis and thymic cell line apoptosis and is alternative coreceptor with CD4 for HIV-1 infection. CCR8 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 30.62 kDa and the accession number is P51685-1.

Expression system: HEK293 Cells
Length: 1-369, Full Length
Activity: ELISA

Expression system: Baculovirus Insect Cells
Length: 21-413, Partial
Activity: Not Tested

Expression system: In vitro E. coli
Length: 1-330, Full Length
Activity: Not Tested

Expression system: HEK293 Cells
Length: 1-472, Full Length
Activity: ELISA

Expression system: E. coli
Length: 22-145, Partial
Activity: Not Tested

C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. CXCR4 stands out for its pleiotropic roles in both physiological and pathological conditions and it represents a crucial target in drug development. CXCL12 is the principal CXCR4 specific ligand and that the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) is also able to bind and activate CXCR4.

Expression system: E. coli
Length: 210-366, Partial
Activity: Not Tested

Expression system: E. coli
Length: 22-580, Partial
Activity: Not Tested

Expression system: in vitro E.coli expression system
Length: 1-360, Full Length
Activity: Not Tested

GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exist in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are bonded and activated by light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters. These ligands vary in size from small molecules to peptides to large proteins. G protein-coupled receptors are involved in many diseases and are also the target of approximately 40% of all modern medicinal drugs. GPR37 is expressed in the brain and spinal cord, and at lower levels in the testis, placenta, and liver, but no detectable expression is observed in any other tissue. GPR37 may have a unique functional role in the central nervous system.

Frizzled 5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.6 kDa and the accession number is Q13467.

CX3CR1 Protein-VLP, Human, Recombinant (Flag & Strep) is expressed in HEK293 Cells. The accession number is P49238.

CCR5 Protein-Nanodisc, Human, Recombinant (Flag-Strep & His) is expressed in HEK293 Cells. The accession number is P51685.

CXCR2 Protein, Human, Recombinant (Flag & His-Strep) is expressed in HEK293 Cells. The accession number is P25025.

CCR2 Protein-VLP, Human, Recombinant (Flag) is expressed in HEK293 Cells. The accession number is P41597-2.

Renin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is P00797-1.

Frizzled 10 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43 kDa and the accession number is Q149J3.

CXCR4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 39.75 kDa and the accession number is P61073-1.

Expression system: HEK293 Cells
Length: 28-172, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-348, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 1-36, Partial
Activity: Not Tested

Expression system: E. coli
Length: 1-390, Full Length
Activity: Not Tested

Expression system: E. coli
Length: 4-50, Partial
Activity: Not Tested