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G Protein-Coupled Receptors, GPCRs

G protein-coupled receptors (GPCRs) form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. GPCRs are found only in eukaryotes, including yeast, and choanoflagellates. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters. GPCRs are involved in many diseases such as mental, metabolic including endocrinological disorders, immunological including viral infections, cardiovascular, inflammatory, senses disorders, and cancer. Therefore, GPCRs are an important drug target and approximately 34% of all Food and Drug Administration (FDA) approved drugs target 108 members of this family.

FilterHomeRecombinant ProteinsReceptor ProteinsG Protein-Coupled Receptors, GPCRs
SSTR2/SSTR2A Protein-VLP, Human, Recombinant
TMPY-06364
SSTR2 SSTR2A Protein-VLP, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 41.34 kDa and the accession number is P30874-1.
  • $838
In Stock
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TSHR Protein, Human, Recombinant (His)
TMPY-04853
Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis.
  • $228
In Stock
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QTY
CNR1 Protein-VLP, Human, Recombinant (His)
TMPH-01035
CNR1 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 54.6 kDa and the accession number is P21554.
  • $530
20 days
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QTY
CXCR4 Protein, Human, Recombinant (hFc)
TMPJ-01037
C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. CXCR4 stands out for its pleiotropic roles in both physiological and pathological conditions and it represents a crucial target in drug development. CXCL12 is the principal CXCR4 specific ligand and that the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) is also able to bind and activate CXCR4.
  • $138
7-10 days
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QTY
CHRM1 Protein, Human, Recombinant (His)
TMPH-01714
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.8 kDa and the accession number is P11229.
  • $284
20 days
Size
QTY
Frizzled 4 Protein, Rat, Recombinant (hFc)
TMPY-03310
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.2 kDa and the accession number is Q9QZH0.
  • $600
7-10 days
Size
QTY
Renin Protein, Human, Recombinant (His)
TMPY-00908
Renin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is P00797-1.
  • $378
In Stock
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Frizzled 10 Protein, Mouse, Recombinant (hFc)
TMPY-01797
Frizzled 10 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43 kDa and the accession number is Q149J3.
  • $700
7-10 days
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QTY
Frizzled 5 Protein, Human, Recombinant (His)
TMPY-01469
Frizzled 5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.6 kDa and the accession number is Q13467.
  • $451
In Stock
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GPR114 Protein, Human, Recombinant (hFc)
TMPY-02837
GPR114 belongs to the G-protein coupled receptor 2 family. Members of this family share a common molecular architecture which consists of seven transmembrane domains, three extracellular loops, three intracellular loops, an amino-terminal extracellular domain, and an intracellular carboxyl terminus. It is thought that light acts as the activating stimulus of a G-protein-coupled receptor (GPCR). GPCRs are expected to have a molecular function (G-protein coupled receptor activity) and to localize in various compartments (endoplasmic reticulum membrane, plasma membrane, integral to the membrane). Family B of the GPCRs is a small but structurally and functionally diverse group of proteins that includes receptors for polypeptide hormones, molecules thought to mediate intercellular interactions at the plasma membrane, and a group of Drosophila proteins that regulate stress responses and longevity. GPR114 contains 1 GPS domain. GPR114 gene has been proposed to participate in processes (G-protein coupled receptor protein signaling pathway, neuropeptide signaling pathway).
  • $600
7-10 days
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CXCR4 Protein, Human, Recombinant
TMPY-06553
CXCR4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 39.75 kDa and the accession number is P61073-1.
  • $838
7-10 days
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GPRC5D Protein, Human, Recombinant (His & FLAG)
TMPY-06719
GPRC5D Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 32.83 kDa and the accession number is Q9NZD1.
  • $2,420
7-10 days
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CCR6 Protein, Human, Recombinant (His & Myc)
TMPH-01066
CCR6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.9 kDa and the accession number is P51684.
  • $284
20 days
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CXCR3 Protein, Mouse, Recombinant (His & KSI)
TMPH-02612
Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21.
  • $360
20 days
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GPR52 Protein, Bovine, Recombinant (His & KSI)
TMPH-00269
GPR52 Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 20.4 kDa and the accession number is A6QLE7.
  • $360
20 days
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CXCR3 Protein, Human, Recombinant (GST & His)
TMPH-01162
CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
  • $284
20 days
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HTRA1 Protein, Mouse, Recombinant (His)
TMPH-02894
HTRA1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 39.0 kDa and the accession number is Q9R118.
  • $284
20 days
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CHRM1 Protein, Rat, Recombinant (His)
TMPH-03338
The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.1 kDa and the accession number is P08482.
  • $284
20 days
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Rhodopsin Protein, Bovine, Recombinant (His & KSI)
TMPH-00300
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Rhodopsin Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 19.5 kDa and the accession number is P02699.
  • $360
20 days
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CCR4 Protein, Human, Recombinant (His & SUMO)
TMPH-01064
High affinity receptor for the C-C type chemokines CCL17 TARC, CCL22 MDC and CKLF isoform 1 CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 19.0 kDa and the accession number is P51679.
  • $237
20 days
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Rhodopsin Protein, Bovine, Recombinant (His)
TMPH-00299
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Rhodopsin Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.0 kDa and the accession number is P02699.
  • $817
20 days
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QTY
Frizzled-8 Protein, Human, Recombinant (His)
TMPJ-01332
Frizzled-8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-32 KDa and the accession number is Q9H461.
  • $143
7-10 days
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HTR1B Protein, Human, Recombinant (His)
TMPH-00859
HTR1B Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 45.1 kDa and the accession number is P28222.
  • $1,980
20 days
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HTRA1 Protein, Human, Recombinant (His & SUMO)
TMPH-02081
HTRA1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
  • $198
20 days
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GPR37 Protein, Human, Recombinant (His)
TMPY-02717
GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exist in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are bonded and activated by light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters. These ligands vary in size from small molecules to peptides to large proteins. G protein-coupled receptors are involved in many diseases and are also the target of approximately 40% of all modern medicinal drugs. GPR37 is expressed in the brain and spinal cord, and at lower levels in the testis, placenta, and liver, but no detectable expression is observed in any other tissue. GPR37 may have a unique functional role in the central nervous system.
  • $700
7-10 days
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Renin Protein, Mouse, Recombinant (His)
TMPY-01231
Renin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.2 kDa and the accession number is P06281.
  • $600
7-10 days
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CD97 Protein, Human, Recombinant (His)
TMPY-01365
CD97 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.6 kDa and the accession number is P48960-2.
  • $600
7-10 days
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QTY
Frizzled 6 Protein, Human, Recombinant (His)
TMPY-04271
Frizzled 6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is A0A024R9E9.
  • $700
7-10 days
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QTY
Frizzled 4 Protein, Human, Recombinant (His)
TMPY-04302
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is Q9ULV1.
  • $357
7-10 days
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GPRC5D Protein, Human, Recombinant, Biotinylated
TMPY-06601
GPRC5D Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.80 kDa and the accession number is Q9NZD1-1.
  • $838
7-10 days
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FZD1/Frizzled 1 Protein, Mouse, Recombinant (hFc)
TMPJ-00354
Frizzled homolog 1 (FZD1), also known as Frizzled-1, a member of the G-protein-coupled receptor superfamily, mediates Wnt signaling by serving as a co-receptor with LRP-5 for Wnt ligands. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.
  • $91
7-10 days
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GLP1R Protein, Mouse, Recombinant (His & SUMO)
TMPH-02676
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.4 kDa and the accession number is O35659.
  • $284
20 days
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GPR107 Protein, Human, Recombinant (His & Myc)
TMPH-01936
GPR107 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
  • $360
20 days
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QTY
GLP1R Protein, Rat, Recombinant (E. coli, His)
TMPH-03301
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P32301.
  • $360
20 days
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Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc)
TMPY-00317
Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.9 kDa and the accession number is P30988-1.
  • $700
7-10 days
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QTY
GLP1R Protein, Rat, Recombinant (His)
TMPH-03302
GLP1R Protein, Rat, Recombinant (His) is expressed in Yeast.
  • $397
20 days
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QTY
DRD1 Protein, Human, Recombinant (His)
TMPH-01200
DRD1 Protein, Human, Recombinant (His) is expressed in E. coli.
  • $237
20 days
Size
QTY
Frizzled 4 Protein, Rat, Recombinant (His)
TMPY-00313
Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is A6I5Z8.
  • $357
7-10 days
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QTY
DRD2 Protein, Human, Recombinant (His & Myc)
TMPH-01201
Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2 KDR activity, downstream of OPN5.
  • $284
20 days
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Rhodopsin Protein, Pig, Recombinant (GST & His)
TMPH-03123
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Rhodopsin Protein, Pig, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 34.2 kDa and the accession number is O18766.
  • $360
20 days
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GCGR Protein, Human, Recombinant (E. coli, His & Myc)
TMPH-01382
GCGR Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.5 kDa and the accession number is P47871.
  • $360
20 days
Size
QTY
GLP1R Protein, Human, Recombinant (E. coli, His)
TMPH-01384
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220.
  • $198
20 days
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GPRC5D Protein-VLP, Mouse, Recombinant (Flag)
TMPY-06807
GPRC5D Protein, Mouse, Recombinant (Flag) is expressed in HEK293 mammalian cells with Flag tag. The predicted molecular weight is 35.8 kDa and the accession number is Q9JIL6-2.
  • $838
7-10 days
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GLP1R Protein, Human, Recombinant (His & Avi)
TMPY-06864
Glucagon-like peptide (GLP)-1 receptor is encoded by GLP1R. GLP1R plays a critical role in mediating the biological actions of GLP1 in mammals and fish. The neuronal GLP1Rs mediate body weight and anorectic effects of liraglutide, but are not required for glucose-lowering effects. Glucagon-like peptide 1 receptor (GLP1R) signaling has been shown to have antipsychotic properties in animal models and to impact glucose-dependent insulin release, satiety, memory, and learning in man. Glucagon-like peptide-1 receptor (GLP1R) and glucose-dependent insulinotropic peptide receptor (GIPR) are their indirect drug targets.
  • $600
7-10 days
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CD97 Protein, Human, Recombinant (hFc)
TMPY-01683
CD97 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 68.2 kDa and the accession number is P48960-2.
  • $600
7-10 days
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GPR56 Protein, Human, Recombinant (His)
TMPY-02276
ADGRG1 (Adhesion G Protein-Coupled Receptor G1, also known as GPR56) is a Protein Coding gene. GPR56 is a member of an adhesion G protein-coupled receptor family with a very long N-terminal stalk and seven transmembrane domains. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. GPR56 may be a target for the treatment of type 2 diabetes. GPR56 inhibits melanoma metastatic growth by impeding the expansion of micrometastases to macrometastases. GPR56 loss of function promotes mesenchymal differentiation and radioresistance of glioma initiating cells both in vitro and in vivo. Diseases associated with ADGRG1 include Polymicrogyria, Bilateral Frontoparietal, and Polymicrogyria, Bilateral Perisylvian, Autosomal Recessive.
  • $600
7-10 days
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TSC22D1 Protein, Mouse, Recombinant (His)
TMPY-02037
TSC22D1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.8 kDa and the accession number is P62500-2.
  • $700
7-10 days
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TSC22D1 Protein, Human, Recombinant (His)
TMPY-02400
TSC22D1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 17.2 kDa and the accession number is Q15714-2.
  • $700
7-10 days
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