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G Protein-Coupled Receptors, GPCRs

G protein-coupled receptors (GPCRs) form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular responses. GPCRs are found only in eukaryotes, including yeast, and choanoflagellates. The ligands that bind and activate these receptors include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters. GPCRs are involved in many diseases such as mental, metabolic including endocrinological disorders, immunological including viral infections, cardiovascular, inflammatory, senses disorders, and cancer. Therefore, GPCRs are an important drug target and approximately 34% of all Food and Drug Administration (FDA) approved drugs target 108 members of this family.

FilterHomeRecombinant ProteinsReceptor ProteinsG Protein-Coupled Receptors, GPCRs
  • CXCR4 Protein, Human, Recombinant (hFc)
    TMPJ-01037
    C-X-C chemokine receptor type 4 (CXCR4) is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1 also called CXCL12), a molecule endowed with potent chemotactic activity for lymphocytes. This receptor is one of several chemokine receptors that HIV isolates can use to infect CD4+ T cells. CXCR4 stands out for its pleiotropic roles in both physiological and pathological conditions and it represents a crucial target in drug development. CXCL12 is the principal CXCR4 specific ligand and that the pro-inflammatory chemokine macrophage migration inhibitory factor (MIF) is also able to bind and activate CXCR4.
    • $138
    7-10 days
    Size
    QTY
  • Frizzled-8 Protein, Human, Recombinant (His)
    TMPJ-01332
    Frizzled-8 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 22-32 KDa and the accession number is Q9H461.
    • $143
    7-10 days
    Size
    QTY
  • Rhodopsin Protein, Bovine, Recombinant (His)
    TMPH-00299
    Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Rhodopsin Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.0 kDa and the accession number is P02699.
    • $817
    20 days
    Size
    QTY
  • Rhodopsin Protein, Bovine, Recombinant (His & KSI)
    TMPH-00300
    Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Rhodopsin Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 19.5 kDa and the accession number is P02699.
    • $360
    20 days
    Size
    QTY
  • GPR52 Protein, Bovine, Recombinant (His & KSI)
    TMPH-00269
    GPR52 Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 20.4 kDa and the accession number is A6QLE7.
    • $360
    20 days
    Size
    QTY
  • HTR1B Protein, Human, Recombinant (His)
    TMPH-00859
    HTR1B Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 45.1 kDa and the accession number is P28222.
    • $1,980
    20 days
    Size
    QTY
  • CCR4 Protein, Human, Recombinant (His & SUMO)
    TMPH-01064
    High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 19.0 kDa and the accession number is P51679.
    • $237
    20 days
    Size
    QTY
  • CCR6 Protein, Human, Recombinant (His & Myc)
    TMPH-01066
    CCR6 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 12.9 kDa and the accession number is P51684.
    • $284
    20 days
    Size
    QTY
  • CXCR3 Protein, Human, Recombinant (GST & His)
    TMPH-01162
    CXCR3 Protein, Human, Recombinant (GST & His) is expressed in E. coli.
    • $284
    20 days
    Size
    QTY
  • HTRA1 Protein, Human, Recombinant (His & SUMO)
    TMPH-02081
    HTRA1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
    • $198
    20 days
    Size
    QTY
  • CHRM1 Protein, Rat, Recombinant (His)
    TMPH-03338
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.1 kDa and the accession number is P08482.
    • $284
    20 days
    Size
    QTY
  • CXCR3 Protein, Mouse, Recombinant (His & KSI)
    TMPH-02612
    Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of mesangial cells through a heterotrimeric G-protein signaling pathway. Probably promotes cell chemotaxis response. Binds to CCL21.
    • $360
    20 days
    Size
    QTY
  • HTRA1 Protein, Mouse, Recombinant (His)
    TMPH-02894
    HTRA1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 39.0 kDa and the accession number is Q9R118.
    • $284
    20 days
    Size
    QTY
  • Renin Protein, Human, Recombinant (His)
    TMPY-00908
    Renin Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.7 kDa and the accession number is P00797-1.
    • $378
    In Stock
    Size
    QTY
  • Frizzled 5 Protein, Human, Recombinant (His)
    TMPY-01469
    Frizzled 5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.6 kDa and the accession number is Q13467.
    • $451
    In Stock
    Size
    QTY
  • Frizzled 10 Protein, Mouse, Recombinant (hFc)
    TMPY-01797
    Frizzled 10 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43 kDa and the accession number is Q149J3.
    • $700
    7-10 days
    Size
    QTY
  • GPR114 Protein, Human, Recombinant (hFc)
    TMPY-02837
    GPR114 belongs to the G-protein coupled receptor 2 family. Members of this family share a common molecular architecture which consists of seven transmembrane domains, three extracellular loops, three intracellular loops, an amino-terminal extracellular domain, and an intracellular carboxyl terminus. It is thought that light acts as the activating stimulus of a G-protein-coupled receptor (GPCR). GPCRs are expected to have a molecular function (G-protein coupled receptor activity) and to localize in various compartments (endoplasmic reticulum membrane, plasma membrane, integral to the membrane). Family B of the GPCRs is a small but structurally and functionally diverse group of proteins that includes receptors for polypeptide hormones, molecules thought to mediate intercellular interactions at the plasma membrane, and a group of Drosophila proteins that regulate stress responses and longevity. GPR114 contains 1 GPS domain. GPR114 gene has been proposed to participate in processes (G-protein coupled receptor protein signaling pathway, neuropeptide signaling pathway).
    • $600
    7-10 days
    Size
    QTY
  • Frizzled 4 Protein, Rat, Recombinant (hFc)
    TMPY-03310
    Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.2 kDa and the accession number is Q9QZH0.
    • $600
    7-10 days
    Size
    QTY
  • CXCR4 Protein, Human, Recombinant
    TMPY-06553
    CXCR4 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 39.75 kDa and the accession number is P61073-1.
    • $838
    7-10 days
    Size
    QTY
  • GPRC5D Protein, Human, Recombinant (His & FLAG)
    TMPY-06719
    GPRC5D Protein, Human, Recombinant (His & FLAG) is expressed in HEK293 mammalian cells with His and Flag tag. The predicted molecular weight is 32.83 kDa and the accession number is Q9NZD1.
    • $2,420
    7-10 days
    Size
    QTY
  • FZD1/Frizzled 1 Protein, Mouse, Recombinant (hFc)
    TMPJ-00354
    Frizzled homolog 1 (FZD1), also known as Frizzled-1, a member of the G-protein-coupled receptor superfamily, mediates Wnt signaling by serving as a co-receptor with LRP-5 for Wnt ligands. The FZD1 protein contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, 7 transmembrane domains, and a C-terminal PDZ domain-binding motif.
    • $91
    7-10 days
    Size
    QTY
  • CNR1 Protein-VLP, Human, Recombinant (His)
    TMPH-01035
    CNR1 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 54.6 kDa and the accession number is P21554.
    • $530
    20 days
    Size
    QTY
  • DRD1 Protein, Human, Recombinant (His)
    TMPH-01200
    DRD1 Protein, Human, Recombinant (His) is expressed in E. coli.
    • $237
    20 days
    Size
    QTY
  • DRD2 Protein, Human, Recombinant (His & Myc)
    TMPH-01201
    Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Positively regulates postnatal regression of retinal hyaloid vessels via suppression of VEGFR2/KDR activity, downstream of OPN5.
    • $284
    20 days
    Size
    QTY
  • GCGR Protein, Human, Recombinant (E. coli, His & Myc)
    TMPH-01382
    GCGR Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 20.5 kDa and the accession number is P47871.
    • $360
    20 days
    Size
    QTY
  • GLP1R Protein, Human, Recombinant (E. coli, His)
    TMPH-01384
    G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220.
    • $198
    20 days
    Size
    QTY
  • CHRM1 Protein, Human, Recombinant (His)
    TMPH-01714
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 20.8 kDa and the accession number is P11229.
    • $284
    20 days
    Size
    QTY
  • GPR107 Protein, Human, Recombinant (His & Myc)
    TMPH-01936
    GPR107 Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
    • $360
    20 days
    Size
    QTY
  • GLP1R Protein, Mouse, Recombinant (His & SUMO)
    TMPH-02676
    G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.4 kDa and the accession number is O35659.
    • $284
    20 days
    Size
    QTY
  • Rhodopsin Protein, Pig, Recombinant (GST & His)
    TMPH-03123
    Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change that activates signaling via G-proteins. Subsequent receptor phosphorylation mediates displacement of the bound G-protein alpha subunit by the arrestin SAG and terminates signaling. Rhodopsin Protein, Pig, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 34.2 kDa and the accession number is O18766.
    • $360
    20 days
    Size
    QTY
  • GLP1R Protein, Rat, Recombinant (E. coli, His)
    TMPH-03301
    G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P32301.
    • $360
    20 days
    Size
    QTY
  • GLP1R Protein, Rat, Recombinant (His)
    TMPH-03302
    GLP1R Protein, Rat, Recombinant (His) is expressed in Yeast.
    • $397
    20 days
    Size
    QTY
  • Frizzled 4 Protein, Rat, Recombinant (His)
    TMPY-00313
    Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is A6I5Z8.
    • $357
    7-10 days
    Size
    QTY
  • Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc)
    TMPY-00317
    Calcitonin receptor Protein, Human, Recombinant (aa 25-154, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 43.9 kDa and the accession number is P30988-1.
    • $700
    7-10 days
    Size
    QTY
  • Renin Protein, Mouse, Recombinant (His)
    TMPY-01231
    Renin Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 43.2 kDa and the accession number is P06281.
    • $600
    7-10 days
    Size
    QTY
  • CD97 Protein, Human, Recombinant (His)
    TMPY-01365
    CD97 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 42.6 kDa and the accession number is P48960-2.
    • $600
    7-10 days
    Size
    QTY
  • GPR37 Protein, Human, Recombinant (His)
    TMPY-02717
    GPR37 (cathepsin Z) is an orphan receptor that belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors are a large protein family comprised of transmembrane receptors that sense molecules outside the cell and activate inside signal transduction pathways and, ultimately, cellular responses. They only exist in eukaryotes, including yeast, choanoflagellates, and animals. These receptors are bonded and activated by light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters. These ligands vary in size from small molecules to peptides to large proteins. G protein-coupled receptors are involved in many diseases and are also the target of approximately 40% of all modern medicinal drugs. GPR37 is expressed in the brain and spinal cord, and at lower levels in the testis, placenta, and liver, but no detectable expression is observed in any other tissue. GPR37 may have a unique functional role in the central nervous system.
    • $700
    7-10 days
    Size
    QTY
  • Frizzled 4 Protein, Human, Recombinant (His)
    TMPY-04302
    Familial exudative vitreoretinopathy (FEVR) is a hereditary blinding disorder that features defects in retinal vascular development. Mutations in FZD4 are known to cause autosomal dominant exudative vitreoretinopathy (EVR1). The mutations in FZD4 are associated with the phenotypes of retinal folds or ectopic macula in FEVR. Frizzled 4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.7 kDa and the accession number is Q9ULV1.
    • $357
    7-10 days
    Size
    QTY
  • Frizzled 6 Protein, Human, Recombinant (His)
    TMPY-04271
    Frizzled 6 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.1 kDa and the accession number is A0A024R9E9.
    • $700
    7-10 days
    Size
    QTY
  • TSHR Protein, Human, Recombinant (His)
    TMPY-04853
    Thyroid-stimulating hormone (TSH) is secreted by the pituitary gland and promotes thyroid growth and function, with increased TSH levels typically associated with hypothyroidism. Immunohistochemical analysis revealed predominantly nuclei/peri-nuclei localization of TSHR in cancerous tissues but cell membrane localization in non-cancerous parts. Overexpression of TSHR was found in a great majority of HCC tissues and associated with unfavorable prognosis.
    • $228
    In Stock
    Size
    QTY
  • GPRC5D Protein, Human, Recombinant, Biotinylated
    TMPY-06601
    GPRC5D Protein, Human, Recombinant, Biotinylated is expressed in HEK293 mammalian cells. The predicted molecular weight is 38.80 kDa and the accession number is Q9NZD1-1.
    • $838
    7-10 days
    Size
    QTY
  • GPRC5D Protein-VLP, Cynomolgus, Recombinant
    TMPK-00528
    Chimeric antigen receptor (CAR) T cells, a type of cell-based immunotherapy, have shown some promising results in multiple myeloma, a bone marrow cancer.The orphan G protein–coupled receptor, class C group 5 member D (GPRC5D), normally expressed only in the hair follicle, Using quantitative immunofluorescence, we determined that GPRC5D protein is expressed on CD138 MM cells from primary marrow samples with a distribution that was similar to, but independent of, BCMA. GPRC5D Protein-VLP, Cynomolgus, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 35.10 kDa and the accession number is A0A2K5W6I7.
    • $1,620
    7-10 days
    Size
    QTY
  • CCR2b Protein-VLP, Human, Recombinant
    TMPK-00879
    The chemokine (C-C motif) receptor 2B (CCR2B) is one of the two isoforms of the receptor for monocyte chemoattractant protein-1 (CCL2), the major chemoattractant for monocytes, involved in an array of chronic inflammatory diseases. The actin-binding protein filamin A (FLNa) as a protein that associates with the carboxyl-terminal tail of CCR2B. FLNa emerges as an important protein for controlling the internalization and spatial localization of the CCR2B receptor in different dynamic membrane structures.
    • $1,620
    7-10 days
    Size
    QTY
  • HTR1D Protein, Human, Recombinant (hFc)
    TMPH-00860
    HTR1D Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 33.1 kDa and the accession number is P28221.
    • $614
    20 days
    Size
    QTY
  • HTR1D Protein, Human, Recombinant (His & KSI)
    TMPH-00861
    HTR1D Protein, Human, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 19.5 kDa and the accession number is P28221.
    • $360
    20 days
    Size
    QTY
  • HTR1F Protein, Human, Recombinant (His & SUMO)
    TMPH-00862
    G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. HTR1F Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO tag. The predicted molecular weight is 60.2 kDa and the accession number is P30939.
    • $1,960
    20 days
    Size
    QTY
  • CCR4 Protein-VLP, Human, Recombinant (His)
    TMPH-01065
    High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. CCR4 Protein-VLP, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-10xHis tag. The predicted molecular weight is 43.2 kDa and the accession number is P51679.
    • $530
    20 days
    Size
    QTY
  • FSHR Protein, Human, Recombinant (E. coli, His)
    TMPH-01347
    G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. FSHR Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 44.0 kDa and the accession number is P23945.
    • $198
    20 days
    Size
    QTY
  • CHRM3 Protein, Human, Recombinant (B2M & His)
    TMPH-01716
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM3 Protein, Human, Recombinant (B2M & His) is expressed in E. coli expression system with N-6xHis-B2M tag. The predicted molecular weight is 40.7 kDa and the accession number is P20309.
    • $198
    20 days
    Size
    QTY
  • CHRM5 Protein, Human, Recombinant (His)
    TMPH-01717
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. CHRM5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 31.5 kDa and the accession number is P08912.
    • $284
    20 days
    Size
    QTY