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Tz-Thalidomide

Catalog No. T77912 CAS 2087490-42-2

Tz-Thalidomide is a tetrazine-modified Thalidomide (E3 ligase ligand) with some affinity for BRD4.

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Tz-Thalidomide, CAS 2087490-42-2

Pack Size	Availability	Price/USD
5 mg	In stock	$ 128.00
10 mg	In stock	$ 213.00
25 mg	In stock	$ 428.00
50 mg	In stock	$ 688.00
100 mg	In stock	$ 1,080.00
1 mL * 10 mM (in DMSO)	In stock	$ 240.00

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Purity: 98.34%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tz-Thalidomide is a tetrazine-modified Thalidomide (E3 ligase ligand) with some affinity for BRD4.
Targets&IC50	BRD4(2):62.55 μM, BRD4(1):46.25 μM

Molecular Weight	571.58
Formula	C29H29N7O6
CAS No.	2087490-42-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 40 mg/mL (69.98 mM), Sonication is recommended.

References and Literature

1. Lebraud H, et al. Protein Degradation by In-Cell Self-Assembly of Proteolysis Targeting Chimeras. ACS Cent Sci. 2016 Dec 28;2(12):927-934.

Related compound libraries

This product is contained In the following compound libraries：

Kinase Inhibitor Library

Related Products

Related compounds with same targets

BRD4 Inhibitor-10 MS436 ZEN-3219 MS645 ZL0580 ZL0590 NSC 228155 FL-411

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tz-Thalidomide 2087490-42-2 Chromatin/Epigenetic Epigenetic Reader Domain inhibitor inhibit

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.