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DG 381B
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Catalog No. TN8310Cas No. 564-16-9
Alias STX122, STX 122, DG381B, 11-Deoxyglycyrrhetinic acid
DG 381B (11-Deoxyglycyrrhetinic acid) has anti-inflammatory and potential anticancer activities, significantly inhibiting gastric cancer cell viability in a dose- and time-dependent manner. It induces apoptosis and G2 cell cycle arrest by upregulating p21 and downregulating cdc2 and cyclin B1 in gastric cancer cells.
DG 381B
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Purity: 95.14%
Catalog No. TN8310Alias STX122, STX 122, DG381B, 11-Deoxyglycyrrhetinic acidCas No. 564-16-9
DG 381B (11-Deoxyglycyrrhetinic acid) has anti-inflammatory and potential anticancer activities, significantly inhibiting gastric cancer cell viability in a dose- and time-dependent manner. It induces apoptosis and G2 cell cycle arrest by upregulating p21 and downregulating cdc2 and cyclin B1 in gastric cancer cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $218 | Inquiry | Inquiry |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.14%
Appearance:Solid
Color:White
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Product Introduction
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| Description | DG 381B (11-Deoxyglycyrrhetinic acid) has anti-inflammatory and potential anticancer activities, significantly inhibiting gastric cancer cell viability in a dose- and time-dependent manner. It induces apoptosis and G2 cell cycle arrest by upregulating p21 and downregulating cdc2 and cyclin B1 in gastric cancer cells. |
| In vitro | DG 381B induced apoptosis and G2 phase cell cycle arrest by up-regulating p21 and down-regulating cdc2 and cyclin B1, and significantly inhibited the viability of gastric cancer cells in a dose - and time-dependent manner. [1] |
| In vivo | DG 381B can effectively inhibit the tumor formation of gastric cancer cells in nude mice. [1] |
| Synonyms | STX122, STX 122, DG381B, 11-Deoxyglycyrrhetinic acid |
| Molecular Weight | 456.7 |
| Formula | C30H48O3 |
| Cas No. | 564-16-9 |
| Smiles | C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O)CC3)[H])(CC=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H] |
| Relative Density. | no data available |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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