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DG 381B
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Catalog No. TN8310Cas No. 564-16-9
Alias STX122, STX 122, DG381B, 11-Deoxyglycyrrhetinic acid
DG 381B (11-Deoxyglycyrrhetinic acid) has anti-inflammatory and potential anticancer activities, significantly inhibiting gastric cancer cell viability in a dose- and time-dependent manner. It induces apoptosis and G2 cell cycle arrest by upregulating p21 and downregulating cdc2 and cyclin B1 in gastric cancer cells.
DG 381B
😃Good
Purity: 95.14%
Catalog No. TN8310Alias STX122, STX 122, DG381B, 11-Deoxyglycyrrhetinic acidCas No. 564-16-9
DG 381B (11-Deoxyglycyrrhetinic acid) has anti-inflammatory and potential anticancer activities, significantly inhibiting gastric cancer cell viability in a dose- and time-dependent manner. It induces apoptosis and G2 cell cycle arrest by upregulating p21 and downregulating cdc2 and cyclin B1 in gastric cancer cells.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 2 mg | $218 | Backorder | Backorder |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:95.14%
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Product Introduction
Bioactivity
Chemical Properties
| Description | DG 381B (11-Deoxyglycyrrhetinic acid) has anti-inflammatory and potential anticancer activities, significantly inhibiting gastric cancer cell viability in a dose- and time-dependent manner. It induces apoptosis and G2 cell cycle arrest by upregulating p21 and downregulating cdc2 and cyclin B1 in gastric cancer cells. |
| In vitro | DG 381B induced apoptosis and G2 phase cell cycle arrest by up-regulating p21 and down-regulating cdc2 and cyclin B1, and significantly inhibited the viability of gastric cancer cells in a dose - and time-dependent manner. [1] |
| In vivo | DG 381B can effectively inhibit the tumor formation of gastric cancer cells in nude mice. [1] |
| Synonyms | STX122, STX 122, DG381B, 11-Deoxyglycyrrhetinic acid |
| Molecular Weight | 456.7 |
| Formula | C30H48O3 |
| Cas No. | 564-16-9 |
| Smiles | C[C@]12[C@@]([C@]3(C)[C@@](CC1)(C(C)(C)[C@@H](O)CC3)[H])(CC=C4[C@@]2(C)CC[C@]5(C)[C@]4(C[C@](C(O)=O)(C)CC5)[H])[H] |
| Relative Density. | no data available |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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