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Tectochrysin
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Catalog No. T3S1775Cas No. 520-28-5
Alias Techtochrysine, Techtochrysin, NSC 80687
1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apoptotic cell death in NSC-LC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation.
Tectochrysin
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Purity: 99.54%
Catalog No. T3S1775Alias Techtochrysine, Techtochrysin, NSC 80687Cas No. 520-28-5
1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apoptotic cell death in NSC-LC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 10 mg | $48 | In Stock | In Stock | |
| 25 mg | $98 | In Stock | In Stock | |
| 50 mg | $174 | In Stock | In Stock | |
| 100 mg | $257 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $45 | In Stock | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information
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Purity:99.54%
Appearance:Solid
Color:White to Yellow
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Product Introduction
Tectochrysin AI Summary
Tectochrysin displays a variety of bioactivities and pharmacological effects. It exhibits in vivo hypoglycemic activity in mice, significantly reducing blood glucose levels from 455.0 mg dl-1 to 399.6 mg dl-1 after 7 days at 50 mg/kg. The compound interacts with P-glycoprotein (PgP), demonstrating significant binding with a Kd value of 6300.0 nM and affecting daunomycin accumulation in PgP-positive leukemic cells. It also displays moderate antioxidant activity in BALB/c mouse bone marrow cells with an IC25 value of 160.0 µM.
In terms of cytotoxicity, Tectochrysin affects various cell lines, including CHO, human COLO205, A431, A549, MCF7, PANC1 under nutrient-deprived conditions, KB, and mouse B16-BL6, HT1080, and 26-L5 cells, with IC50 or EC50 values indicating variable potency. It shows low cytotoxicity against human PANC1 cells, with a PC100 value greater than 256.0 µM. The compound also has significant antiproliferative effects on multiple cell lines, including SW480, HT-29, DLD1, and HepG2, with IC50 values greater than 20000.0 nM.
Tectochrysin possesses immunomodulatory properties, inhibiting nitric oxide production in LPS-stimulated mouse macrophages and preventing cell degranulation in rat RBL2H3 cells. It has notable interactions with various receptors and enzymes, showing binding affinity to the GABAA receptor (logKi of 1.699), inhibition of rat alpha-glucosidase (IC50 value of 28.7 µg/ml), and human ABCG2 (IC50 value of 3000.0 nM). The compound also demonstrates antitrypanosomal activity against Trypanosoma brucei brucei with an IC50 value of less than 30000.0 nM, inhibition of IL1-induced tissue factor expression in human monocytes, and induction of adipogenesis in mouse 3T3L1 cells at 30 µM.
Additionally, Tectochrysin inhibits Cytochrome P450 enzymes, exhibits potential as a chaperone treatment for Gaucher Disease, influences genotoxicity and DNA repair, and interacts with proteins such as MITF, Nrf2, and others. Its hydrophobicity index is 0.719 with a LogP value of 6.06, indicating a preference for a hydrophobic environment..
Note: Summary generated by AI. Data source: ChEMBL 
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | 1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apoptotic cell death in NSC-LC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation. |
| Synonyms | Techtochrysine, Techtochrysin, NSC 80687 |
| Molecular Weight | 268.26 |
| Formula | C16H12O4 |
| Cas No. | 520-28-5 |
| Smiles | COc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1 |
| Relative Density. | 1.329 g/cm3 (Predicted) |
| Storage | keep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble DMSO: 3.75 mg/mL (13.98 mM), Sonication is recommended.  | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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