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Tectochrysin

Name: Tectochrysin
Brand: TargetMol
SKU: T3S1775
Price: 45 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: Techtochrysine, Techtochrysin, NSC 80687) Copy Product Info

🥰Excellent

Synonyms: Techtochrysine, Techtochrysin, NSC 80687

Catalog No. T3S1775 Copy Product Info

Purity: 99.54%

🥰Excellent

1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apoptotic cell death in NSC-LC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation.

Cas No. 520-28-5

Pack Size	Price	USA Stock	Global Stock
10 mg	$48	In Stock	In Stock
25 mg	$98	In Stock	In Stock
50 mg	$174	In Stock	In Stock
100 mg	$257	-	In Stock
1 mL x 10 mM (in DMSO)	$45	In Stock	In Stock

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Batch Information

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Purity:99.54%

Appearance:Solid

Color:White to Yellow

Resource Download

COA HNMR LCMS

Product Introduction

Tectochrysin AI Summary

Tectochrysin displays a variety of bioactivities and pharmacological effects. It exhibits in vivo hypoglycemic activity in mice, significantly reducing blood glucose levels from 455.0 mg dl-1 to 399.6 mg dl-1 after 7 days at 50 mg/kg. The compound interacts with P-glycoprotein (PgP), demonstrating significant binding with a Kd value of 6300.0 nM and affecting daunomycin accumulation in PgP-positive leukemic cells. It also displays moderate antioxidant activity in BALB/c mouse bone marrow cells with an IC25 value of 160.0 µM. In terms of cytotoxicity, Tectochrysin affects various cell lines, including CHO, human COLO205, A431, A549, MCF7, PANC1 under nutrient-deprived conditions, KB, and mouse B16-BL6, HT1080, and 26-L5 cells, with IC50 or EC50 values indicating variable potency. It shows low cytotoxicity against human PANC1 cells, with a PC100 value greater than 256.0 µM. The compound also has significant antiproliferative effects on multiple cell lines, including SW480, HT-29, DLD1, and HepG2, with IC50 values greater than 20000.0 nM. Tectochrysin possesses immunomodulatory properties, inhibiting nitric oxide production in LPS-stimulated mouse macrophages and preventing cell degranulation in rat RBL2H3 cells. It has notable interactions with various receptors and enzymes, showing binding affinity to the GABAA receptor (logKi of 1.699), inhibition of rat alpha-glucosidase (IC50 value of 28.7 µg/ml), and human ABCG2 (IC50 value of 3000.0 nM). The compound also demonstrates antitrypanosomal activity against Trypanosoma brucei brucei with an IC50 value of less than 30000.0 nM, inhibition of IL1-induced tissue factor expression in human monocytes, and induction of adipogenesis in mouse 3T3L1 cells at 30 µM. Additionally, Tectochrysin inhibits Cytochrome P450 enzymes, exhibits potential as a chaperone treatment for Gaucher Disease, influences genotoxicity and DNA repair, and interacts with proteins such as MITF, Nrf2, and others. Its hydrophobicity index is 0.719 with a LogP value of 6.06, indicating a preference for a hydrophobic environment..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	1. Tectochrysin (Techtochrysine) has antioxidant effect. 2. Tectochrysin is promising inhibitors for the reversal of ABCG2-mediated drug transport. 3. Tectochrysin leads to apoptotic cell death in NSC-LC cells through activation of DR3 and Fas expression via inhibition of STAT3 phosphorylation.
Synonyms	Techtochrysine, Techtochrysin, NSC 80687

Chemical Properties

Molecular Weight	268.26
Formula	C₁₆H₁₂O₄
Cas No.	520-28-5
Smiles	COc1cc(O)c2c(c1)oc(cc2=O)-c1ccccc1
Relative Density.	1.329 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Keep away from direct sunlight,Keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble

DMSO: 12 mg/mL (44.73 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: < 1.2 mg/mL (4.47 mM), Lower concentrations may be soluble, but exact solubility limit is unknown.

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 1.2 mg/mL (4.47 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.7277 mL	18.6386 mL	37.2773 mL	186.3863 mL
5 mM	0.7455 mL	3.7277 mL	7.4555 mL	37.2773 mL
10 mM	0.3728 mL	1.8639 mL	3.7277 mL	18.6386 mL
20 mM	0.1864 mL	0.9319 mL	1.8639 mL	9.3193 mL

Note : The dilution table applies only to solid products. For liquid products, please calculate the stock solution based on the stated concentration and/or density.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 µL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 µL Tween 80 and mix well until fully clarified.

3) Add 450 µL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc