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Apigenin-7-glucuronide

Name: Apigenin-7-glucuronide
Brand: TargetMol
SKU: T5S1026
Price: 40 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T5S1026Cas No. 29741-09-1

Alias Apigenin 7-O-glucuronide

Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively).

Apigenin-7-glucuronide

🥰Excellent

Purity: 99.59%

Catalog No. T5S1026Alias Apigenin 7-O-glucuronideCas No. 29741-09-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$40	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$156	In Stock	In Stock
25 mg	$262	In Stock	In Stock
50 mg	$389	In Stock	In Stock
100 mg	$572	In Stock	In Stock
200 mg	$853	In Stock	-
1 mL x 10 mM (in DMSO)	$108	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.59%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively).
Targets&IC50	MMP13:0.27 μM, MMP3:12.87 μM, MMP8:22.39 μM, MMP9:17.52 μM
In vivo	Apigenin-7-O-β-D-glucuronide (AG) suppressed the release of nitric oxide (NO), prostaglandin E2 (PGE2), and tumour necrosis factor-α (TNF-α) in LPS-stimulated RAW 264.7 macrophages in a dose-dependent manner without affecting cell viability. Additionally, AG suppressed LPS-induced mRNA expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and TNF-α. AG treatment decreased the translocation of c-Jun into the nucleus and decreased activator protein-1 (AP-1)-mediated luciferase activity through the inhibition of both p38 mitogen-activated protein kinase (MAPK) and extracellular signal-regulated kinase (ERK) phosphorylation [2].
Synonyms	Apigenin 7-O-glucuronide

Chemical Properties

Molecular Weight	446.36
Formula	C₂₁H₁₈O₁₁
Cas No.	29741-09-1
Smiles	O[C@H]1[C@H](Oc2cc(O)c3c(c2)oc(cc3=O)-c2ccc(O)cc2)O[C@@H]([C@@H](O)[C@@H]1O)C(O)=O
Relative Density.	1.737 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (112.02 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.48 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2403 mL	11.2017 mL	22.4034 mL	112.0172 mL
5 mM	0.4481 mL	2.2403 mL	4.4807 mL	22.4034 mL
10 mM	0.2240 mL	1.1202 mL	2.2403 mL	11.2017 mL
20 mM	0.1120 mL	0.5601 mL	1.1202 mL	5.6009 mL
50 mM	0.0448 mL	0.2240 mL	0.4481 mL	2.2403 mL
100 mM	0.0224 mL	0.1120 mL	0.2240 mL	1.1202 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc