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9-hydroxy Stearic Acid

Name: 9-hydroxy Stearic Acid
Brand: TargetMol
SKU: T37067
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T37067Cas No. 3384-24-5

9-hydroxy Stearic Acid is a hydroxy fatty acid that is the active metabolite of 9-PAHSA. 9-hydroxy Stearic Acid is formed from 9-PAHSA through carboxyl ester lipase in the liver and pancreas. The 9-hydroxy Stearic Acid (5 μM) was stearic acid, which inhibited the expression of histone deacetylase 1 (HDAC1) in the lysate of HT-29 colon cancer cells. 3. When the concentration was 100 μM.1, the proliferation of HT-29 cells was inhibited and cell cycle arrest was induced in G0/ g1 phase.

9-hydroxy Stearic Acid

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Purity: 99.7%

Catalog No. T37067Cas No. 3384-24-5

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$172	In Stock	In Stock
10 mg	$297	In Stock	In Stock
25 mg	$492	In Stock	In Stock
50 mg	$718	In Stock	In Stock
100 mg	$987	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

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Batch Information

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Purity:99.7%

Appearance:Solid

Color:White

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description

In vitro

9-hydroxy Stearic acid is a hydroxy fatty acid and an active metabolite of 9-PAHSA .[1][2]
It is formed from 9-PAHSA by liver and pancreatic carboxyl ester lipases.2 9-hydroxy Stearic acid (5 µM) inhibits histone deacetylase 1 (HDAC1) in HT-29 colon cancer cell lysates.[3]
It inhibits the proliferation of, and induces cell cycle arrest at the G0/G1 phase in, HT-29 cells when used at a concentration of 100 µM.1.[1]

Chemical Properties

Molecular Weight	300.48
Formula	C₁₈H₃₆O₃
Cas No.	3384-24-5
Smiles	C(C(CCCCCCCCC)O)CCCCCCC(O)=O

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (199.68 mM), Sonication is recommended.

Chloroform: Soluble

In Vivo Formulation

10% DMSO+90% Corn Oil: 2.5 mg/mL (8.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.3280 mL	16.6400 mL	33.2801 mL	166.4004 mL
5 mM	0.6656 mL	3.3280 mL	6.6560 mL	33.2801 mL
10 mM	0.3328 mL	1.6640 mL	3.3280 mL	16.6400 mL
20 mM	0.1664 mL	0.8320 mL	1.6640 mL	8.3200 mL
50 mM	0.0666 mL	0.3328 mL	0.6656 mL	3.3280 mL
100 mM	0.0333 mL	0.1664 mL	0.3328 mL	1.6640 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc