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E3 ligase Ligand 8

Name: E3 ligase Ligand 8
Brand: TargetMol
SKU: T17879
Price: 41 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T17879Cas No. 1225383-33-4

E3 ligase Ligand 8, a ligand for E3 ubiquitin ligase, can be connected to protein ligands through linkers to form PROTACs, which induce ubiquitination-mediated degradation of cancer-promoting proteins.

E3 ligase Ligand 8

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Purity: 98.86%

Catalog No. T17879Cas No. 1225383-33-4

Pack Size	Price	Availability
25 mg	$41	In Stock
50 mg	$67	In Stock
100 mg	$109	In Stock

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Batch Information

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Purity:98.86%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description

Chemical Properties

Molecular Weight	530.61
Formula	C₃₁H₃₄N₂O₆
Cas No.	1225383-33-4
Smiles	CC(C)C[C@H](NC(=O)[C@@H](O)[C@@H](Cc1ccccc1)NC(=O)OCC1c2ccccc2-c2ccccc12)C(O)=O
Relative Density.	1.252 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90 mg/mL (169.62 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8846 mL	9.4231 mL	18.8462 mL	94.2312 mL
5 mM	0.3769 mL	1.8846 mL	3.7692 mL	18.8462 mL
10 mM	0.1885 mL	0.9423 mL	1.8846 mL	9.4231 mL
20 mM	0.0942 mL	0.4712 mL	0.9423 mL	4.7116 mL
50 mM	0.0377 mL	0.1885 mL	0.3769 mL	1.8846 mL
100 mM	0.0188 mL	0.0942 mL	0.1885 mL	0.9423 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc