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(S,R,S)-AHPC-PEG2-NH2 dihydrochloride

🥰Excellent
Catalog No. T18675Cas No. 2341796-76-5
Alias VH032-PEG2-NH2 dihydrochloride, VH032-linker 12, VH032 amide-PEG2-amine

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker[1].

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride
Other Forms of (S,R,S)-AHPC-PEG2-NH2 dihydrochloride:

(S,R,S)-AHPC-PEG2-NH2 dihydrochloride

🥰Excellent
Catalog No. T18675Alias VH032-PEG2-NH2 dihydrochloride, VH032-linker 12, VH032 amide-PEG2-amineCas No. 2341796-76-5
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker[1].
Pack SizePriceAvailabilityQuantity
5 mg$34In Stock
10 mg$55In Stock
25 mg$113In Stock
50 mg$178In Stock
100 mg$255In Stock
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Product Introduction

Bioactivity
Description
(S,R,S)-AHPC-PEG2-NH2 dihydrochloride (VH032-linker 12) is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S,R,S)-AHPC-based VHL ligand and a 2-unit PEG linker[1].
In vitro
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
SynonymsVH032-PEG2-NH2 dihydrochloride, VH032-linker 12, VH032 amide-PEG2-amine
Chemical Properties
Molecular Weight648.64
FormulaC28H43Cl2N5O6S
Cas No.2341796-76-5
SmilesCC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)COCCOCCN)O.Cl.Cl
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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%
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Keywords

VHLVH032-PEG2-NH2 DihydrochlorideVH032-PEG2-NH2LigandforE3LigaseLigand for E3 LigaseInhibitorinhibitE3 Ligase Ligand-Linker ConjugatesAHPC-PEG2-NH2 DihydrochlorideAHPC-PEG2-NH2(S,R,S)-AHPC-PEG-2-NH2 dihydrochloride(S,R,S)AHPCPEG2NH2 dihydrochloride(S,R,S) AHPC PEG2 NH2 dihydrochloride
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