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Anti-NEDD8 Antibody (1Q389)
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Catalog No. TMAB-09338
Anti-NEDD8 Antibody (1Q389) is a Rabbit antibody targeting NEDD8. Anti-NEDD8 Antibody (1Q389) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP.
Anti-NEDD8 Antibody (1Q389)
Anti-NEDD8 Antibody (1Q389)
😃Good
Catalog No. TMAB-09338
Anti-NEDD8 Antibody (1Q389) is a Rabbit antibody targeting NEDD8. Anti-NEDD8 Antibody (1Q389) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 25 μL | $148 | 7-10 days | 7-10 days | |
| 50 μL | $261 | 7-10 days | 7-10 days | |
| 100 μL | $471 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-NEDD8 Antibody (1Q389) is a Rabbit antibody targeting NEDD8. Anti-NEDD8 Antibody (1Q389) can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF,IP. |
| Ig Type | IgG |
| Clone | 1Q389 |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:50-200; IF: 1:100-500; IP: 1:20-50 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Subcellular Localization | Nucleus. Note=Mainly nuclear. |
| Tissue Specificity | Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. |
| Construction | Recombinant Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 10mM phosphate buffered saline (pH 7.4) with 150mM sodium chloride, 0.05% BSA, 0.02% Proclin300 and 50% glycerol. |
| Research Background | Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis via its conjugation to a limited number of cellular proteins, such as cullins or p53/TP53.Attachment of NEDD8 to cullins is critical for the recruitment of E2 to the cullin-RING-based E3 ubiquitin-protein ligase complex, thus facilitating polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. |
| Immunogen | A synthesized peptide: human NEDD8 |
| Antigen Species | Human |
| Gene Name | NEDD8 |
| Gene ID | |
| Protein Name | NEDD8 |
| Uniprot ID | |
| Function | Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. |
| Molecular Weight | Theoretical: 9 kDa. Actual: 10, 90 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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