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1-Methyl-2-undecyl-4(1H)-quinolone

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Catalog No. TN2553Cas No. 59443-02-6
Alias 1-Methyl-2-undecylquinolin-4(1H)-one

1-Methyl-2-undecyl-4(1H)-quinolone, along with dihydroevocarpine and evodiamine, should serve as chemical markers for the quality control of Evodia rutaecarpa (Juss.) Benth. This compound selectively inhibits type B MAO (MAO-B) activity with an IC(50) value of 15.3 microM using the substrate kynuramine, while not inhibiting type A MAO (MAO-A) activity. It can mitigate high phosphate-induced calcification in human aortic valve interstitial cells (HAVICs) by inhibiting phosphate cotransporter (PiT-1) gene expression and exhibits moderate antiangiogenic activity against human tumor cells.

1-Methyl-2-undecyl-4(1H)-quinolone

1-Methyl-2-undecyl-4(1H)-quinolone

😃Good
Catalog No. TN2553Alias 1-Methyl-2-undecylquinolin-4(1H)-oneCas No. 59443-02-6
1-Methyl-2-undecyl-4(1H)-quinolone, along with dihydroevocarpine and evodiamine, should serve as chemical markers for the quality control of Evodia rutaecarpa (Juss.) Benth. This compound selectively inhibits type B MAO (MAO-B) activity with an IC(50) value of 15.3 microM using the substrate kynuramine, while not inhibiting type A MAO (MAO-A) activity. It can mitigate high phosphate-induced calcification in human aortic valve interstitial cells (HAVICs) by inhibiting phosphate cotransporter (PiT-1) gene expression and exhibits moderate antiangiogenic activity against human tumor cells.
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Bioactivity
Description
1-Methyl-2-undecyl-4(1H)-quinolone, along with dihydroevocarpine and evodiamine, should serve as chemical markers for the quality control of Evodia rutaecarpa (Juss.) Benth. This compound selectively inhibits type B MAO (MAO-B) activity with an IC(50) value of 15.3 microM using the substrate kynuramine, while not inhibiting type A MAO (MAO-A) activity. It can mitigate high phosphate-induced calcification in human aortic valve interstitial cells (HAVICs) by inhibiting phosphate cotransporter (PiT-1) gene expression and exhibits moderate antiangiogenic activity against human tumor cells.
Targets&IC50
MAO-B:9.91 μM (Ki), MAO-B:15.3 μM (IC50)
Synonyms1-Methyl-2-undecylquinolin-4(1H)-one
Chemical Properties
Molecular Weight313.48
FormulaC21H31NO
Cas No.59443-02-6
Relative Density.0.975 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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Keywords

MAO-B1-Methyl-2-undecyl-4(1H)-quinolone1Methyl2undecyl4(1H)quinolone1 Methyl 2 undecyl 4(1H) quinolone
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