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GNE-5729

Name: GNE-5729
Brand: TargetMol
SKU: T15408
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15408Cas No. 2026635-66-3

Alias GNE5729

GNE-5729 is a positive allosteric modulator of NMDAR with the advantage of crossing the blood-brain barrier and being orally available, with EC50 values of 37 nM, 4.7 μM and 9.5 μM for GluN2A, GluN2C and GluN2D, respectively, and can be used for the study of neurological and psychiatric disorders.

GNE-5729

🥰Excellent

Purity: 99.85%

Catalog No. T15408Alias GNE5729Cas No. 2026635-66-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$263	-	In Stock
5 mg	$645	-	In Stock
10 mg	$987	-	In Stock
25 mg	$1,980	-	In Stock
50 mg	$3,180	-	In Stock
100 mg	$4,300	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Purity:99.85%

ee:99.66%

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COA CNMR CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	GNE-5729 is a positive allosteric modulator of NMDAR with the advantage of crossing the blood-brain barrier and being orally available, with EC50 values of 37 nM, 4.7 μM and 9.5 μM for GluN2A, GluN2C and GluN2D, respectively, and can be used for the study of neurological and psychiatric disorders.
Targets&IC50	GluN2A:37 nM (EC50), GluN2C:4.7 μM (EC50), GluN2D:9.5 μM (EC50)
In vitro	GNE-5729 is a brain-penetrant positive allosteric modulator of NMDA receptors, showing selective enhancement of GluN2A activity (EC₅₀ = 37 nM), with much weaker effects on GluN2C and GluN2D subtypes (EC₅₀ = 4.7 μM and 9.5 μM, respectively) [1].
Synonyms	GNE5729

Chemical Properties

Molecular Weight	428.2
Formula	C₁₇H₁₀Cl₂F₃N₅O
Cas No.	2026635-66-3
Smiles	ClC1=C(N2C(=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)C=C1)[C@H]4[C@H](C#N)C4
Relative Density.	1.71 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (186.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3354 mL	11.6768 mL	23.3536 mL	116.7679 mL
5 mM	0.4671 mL	2.3354 mL	4.6707 mL	23.3536 mL
10 mM	0.2335 mL	1.1677 mL	2.3354 mL	11.6768 mL
20 mM	0.1168 mL	0.5838 mL	1.1677 mL	5.8384 mL
50 mM	0.0467 mL	0.2335 mL	0.4671 mL	2.3354 mL
100 mM	0.0234 mL	0.1168 mL	0.2335 mL	1.1677 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc