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GNE-5729

Name: GNE-5729
Brand: TargetMol
SKU: T15408
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15408Cas No. 2026635-66-3

Alias GNE5729

GNE-5729 is a positive allosteric modulator of NMDAR with the advantage of crossing the blood-brain barrier and being orally available, with EC50 values of 37 nM, 4.7 μM and 9.5 μM for GluN2A, GluN2C and GluN2D, respectively, and can be used for the study of neurological and psychiatric disorders.

GNE-5729

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Purity: 99.85%

Catalog No. T15408Alias GNE5729Cas No. 2026635-66-3

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$263	-	In Stock
5 mg	$645	-	In Stock
10 mg	$987	-	In Stock
25 mg	$1,980	-	In Stock
50 mg	$3,180	-	In Stock
100 mg	$4,300	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.85%

ee:99.66%

Appearance:Solid

Color:White to Yellow

Resource Download

COA CNMR CSFC FNMR HNMR LCMS ORP

Product Introduction

Bioactivity

Description	GNE-5729 is a positive allosteric modulator of NMDAR with the advantage of crossing the blood-brain barrier and being orally available, with EC50 values of 37 nM, 4.7 μM and 9.5 μM for GluN2A, GluN2C and GluN2D, respectively, and can be used for the study of neurological and psychiatric disorders.
Targets&IC50	GluN2D:9.5 μM (EC50), GluN2C:4.7 μM (EC50), GluN2A:37 nM (EC50)
In vitro	GNE-5729 is a brain-penetrant positive allosteric modulator of NMDA receptors, showing selective enhancement of GluN2A activity (EC₅₀ = 37 nM), with much weaker effects on GluN2C and GluN2D subtypes (EC₅₀ = 4.7 μM and 9.5 μM, respectively) [1].
Synonyms	GNE5729

Chemical Properties

Molecular Weight	428.2
Formula	C₁₇H₁₀Cl₂F₃N₅O
Cas No.	2026635-66-3
Smiles	ClC1=C(N2C(=NC(CN3N=C(C(F)(F)F)C=C3Cl)=CC2=O)C=C1)[C@H]4[C@H](C#N)C4
Relative Density.	1.71 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (186.83 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.71 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3354 mL	11.6768 mL	23.3536 mL	116.7679 mL
5 mM	0.4671 mL	2.3354 mL	4.6707 mL	23.3536 mL
10 mM	0.2335 mL	1.1677 mL	2.3354 mL	11.6768 mL
20 mM	0.1168 mL	0.5838 mL	1.1677 mL	5.8384 mL
50 mM	0.0467 mL	0.2335 mL	0.4671 mL	2.3354 mL
100 mM	0.0234 mL	0.1168 mL	0.2335 mL	1.1677 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc