TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His & hFc)

Catalog No. TMPY-01161

TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with hHis and Fc tag. The predicted molecular weight is 57 kDa and the accession number is AAC39862.1.

TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His & hFc)

Catalog No. TMPY-01161

Pack Size	Price	Availability	Quantity
100 μg	$700	7-10 days

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Product Information

Biological Activity	Activity testing is in progress. It is theoretically active, but we cannot guarantee it. If you require protein activity, we recommend choosing the eukaryotic expression version first.
Description	TIM-1/KIM-1/HAVCR1 Protein, Human, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with hHis and Fc tag. The predicted molecular weight is 57 kDa and the accession number is AAC39862.1.
Species	Human
Expression System	HEK293 Cells
Tag	C-His, N-hFc
Accession Number	AAC39862.1
Synonyms	TIMD-1,TIMD1,TIM-1,TIM1,TIM,KIM-1,KIM1,hepatitis A virus cellular receptor 1,HAVCR-1,HAVCR,HACVR,CD365
Construction	A DNA sequence encoding the mature form of human KIM1 extracellular domain (AAC39862.1) (Ser 21-Gly 290) was fused with a polyhistidine tag at the C-terminus and the Fc region of human IgG1 at the N-terminus. Predicted N terminal: Glu
Protein Purity	> 92 % as determined by SDS-PAGE
Molecular Weight	57 kDa (predicted); 120-140 kDa (reducing condition, due to glycosylation)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution	A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage	It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice.
Research Background	HAV cellular receptor 1 (HAVCR1), also known as Kidney injury molecule 1 (KIM-1) and T cell immunoglobulin mucin 1 (TIM-1), is a type of integral membrane glycoprotein. KIM-1 protein is widely expressed with the highest levels in the kidney and testis. It has been shown to play a major role as a human susceptibility gene for asthma, allergy, and autoimmunity. IgA1lambda is a specific ligand of KIM-1 protein and that their association has a synergistic effect in virus-receptor interactions. KIM-1 involves in the pathogenesis of acute kidney injury. It had been confirmed that KIM-1 is a human urinary renal dysfunction biomarker. Moreover, KIM-1 protein is a novel regulatory molecule of flow-induced calcium signaling.