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Sograzepide

Name: Sograzepide
Brand: TargetMol
SKU: T16906
Price: 799 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T16906Cas No. 155488-25-8

Alias YM-220, YM220, YF476, YF 476, Netazepide

Sograzepide (Netazepide) is an orally active, selective and highly potent gastrin/CCK-B antagonist that inhibits gastrin/CCK-A activity and pappalysin 2 expression in type 1 gastric neuroendocrine tumors, and can induce regression of type 1 gastric neuroendocrine tumors.

Sograzepide

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Catalog No. T16906Alias YM-220, YM220, YF476, YF 476, NetazepideCas No. 155488-25-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$99	-	In Stock
5 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$799	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Sograzepide (Netazepide) is an orally active, selective and highly potent gastrin/CCK-B antagonist that inhibits gastrin/CCK-A activity and pappalysin 2 expression in type 1 gastric neuroendocrine tumors, and can induce regression of type 1 gastric neuroendocrine tumors.
Targets&IC50	Gastrin/CCK-A:501 nM, Gastrin/CCK-B:0.1 nM
In vivo	Intravenous Sograzepide (0.1 μmol/kg) inhibited gastrin-induced gastric acid secretion in anesthetized rats at a dose of ED50 = 87 nM/kg. [1] At a dose of 10 μM/kg, Sograzepide showed inhibition of gastrin-induced gastric acid secretion with an ED50 = 0.0086 μM/kg, but had no effect on histamine- and bethanechol-induced gastric acid secretion. [2]
Synonyms	YM-220, YM220, YF476, YF 476, Netazepide

Chemical Properties

Molecular Weight	498.58
Formula	C₂₈H₃₀N₆O₃
Cas No.	155488-25-8
Smiles	C(C(C(C)(C)C)=O)N1C=2C(C(=N[C@@H](NC(NC3=CC(NC)=CC=C3)=O)C1=O)C4=CC=CC=N4)=CC=CC2
Relative Density.	1.25 g/cm3

Storage & Solubility Information

Storage

store at low temperature | Pure form: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (160.46 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.62 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.0057 mL	10.0285 mL	20.0570 mL	100.2848 mL
5 mM	0.4011 mL	2.0057 mL	4.0114 mL	20.0570 mL
10 mM	0.2006 mL	1.0028 mL	2.0057 mL	10.0285 mL
20 mM	0.1003 mL	0.5014 mL	1.0028 mL	5.0142 mL
50 mM	0.0401 mL	0.2006 mL	0.4011 mL	2.0057 mL
100 mM	0.0201 mL	0.1003 mL	0.2006 mL	1.0028 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc