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S 3304

Name: S 3304
Brand: TargetMol
SKU: T16966
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T16966Cas No. 203640-27-1

S 3304 is a novel matrix metalloproteinase inhibitor, specifically targeting MMP-2 and MMP-9.

S 3304

🥰Excellent

Purity: 98.09%

Catalog No. T16966Cas No. 203640-27-1

S 3304 is a novel matrix metalloproteinase inhibitor, specifically targeting MMP-2 and MMP-9.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$37	In Stock	In Stock
5 mg	$113	In Stock	In Stock
10 mg	$191	In Stock	In Stock
25 mg	$316	In Stock	In Stock
50 mg	$445	In Stock	In Stock
100 mg	$601	In Stock	In Stock
200 mg	$805	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$116	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.09%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	S 3304 is a novel matrix metalloproteinase inhibitor, specifically targeting MMP-2 and MMP-9.
In vitro	S 3304 is a novel D-tryptophan derivative and a potent, noncytotoxic matrix metalloproteinase inhibitor. It most effectively inhibits MMP-2 and MMP-9 activities but does not inhibit MMP-1, MMP-3, or MMP-7, potentially avoiding the musculoskeletal side effects associated with nonspecific inhibitors [1].
In vivo	S 3304 (p.o., the dose range of 20 to 200 mg/kg) treatment, inhibits angiogenesis, artificially induced in mice by the dorsal air-sac method. Similar oral doses of S 3304 cause effective inhibition of metastatic lung colonization of Lewis murine lung carcinoma injected via tail vein and liver metastasis of C-1H human colon cancer implanted into the spleen [1].

Chemical Properties

Molecular Weight	464.56
Formula	C₂₄H₂₀N₂O₄S₂
Cas No.	203640-27-1
Smiles	Cc1ccc(cc1)C#Cc1ccc(s1)S(=O)(=O)N[C@H](Cc1c[nH]c2ccccc12)C(O)=O
Relative Density.	1.47 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 83.3 mg/mL (179.31 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.1 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1526 mL	10.7629 mL	21.5257 mL	107.6287 mL
5 mM	0.4305 mL	2.1526 mL	4.3051 mL	21.5257 mL
10 mM	0.2153 mL	1.0763 mL	2.1526 mL	10.7629 mL
20 mM	0.1076 mL	0.5381 mL	1.0763 mL	5.3814 mL
50 mM	0.0431 mL	0.2153 mL	0.4305 mL	2.1526 mL
100 mM	0.0215 mL	0.1076 mL	0.2153 mL	1.0763 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc