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Maralixibat Chloride

Name: Maralixibat Chloride
Brand: TargetMol
SKU: T32873
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T32873Cas No. 228113-66-4

Alias SHP-625 chloride, SHP625 chloride, SHP 625 chloride, LUM001 chloride, Lopixibat chloride, Livmarli chloride

Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.

Maralixibat Chloride

🥰Excellent

Purity: 99.65%

Catalog No. T32873Alias SHP-625 chloride, SHP625 chloride, SHP 625 chloride, LUM001 chloride, Lopixibat chloride, Livmarli chlorideCas No. 228113-66-4

Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.

Pack Size	Price	Availability
1 mg	$263	In Stock
5 mg	$496	In Stock
10 mg	$745	In Stock
25 mg	$1,330	In Stock
50 mg	$1,880	In Stock
100 mg	$2,630	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.65%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.
Targets&IC50	Ileal sodium-dependent bile acid transporters:0.89 μM
In vivo	Maralixibat chloride can increase the level of sBA and reduce liver injury in cholestatic rats by partial bile duct ligation[1].
Synonyms	SHP-625 chloride, SHP625 chloride, SHP 625 chloride, LUM001 chloride, Lopixibat chloride, Livmarli chloride

Chemical Properties

Molecular Weight	710.41
Formula	C₄₀H₅₆ClN₃O₄S
Cas No.	228113-66-4
Smiles	[Cl-].CCCCC1(CCCC)CS(=O)(=O)c2ccc(cc2[C@H]([C@H]1O)c1ccc(OCc2ccc(C[N+]34CCN(CC3)CC4)cc2)cc1)N(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 35 mg/mL (49.27 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4076 mL	7.0382 mL	14.0764 mL	70.3819 mL
5 mM	0.2815 mL	1.4076 mL	2.8153 mL	14.0764 mL
10 mM	0.1408 mL	0.7038 mL	1.4076 mL	7.0382 mL
20 mM	0.0704 mL	0.3519 mL	0.7038 mL	3.5191 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc