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Maralixibat Chloride

Name: Maralixibat Chloride
Brand: TargetMol
SKU: T32873
Price: 263 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T32873Cas No. 228113-66-4

Alias SHP-625 chloride, SHP625 chloride, SHP 625 chloride, LUM001 chloride, Lopixibat chloride, Livmarli chloride

Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.

Maralixibat Chloride

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Purity: 99.99%

Catalog No. T32873Alias SHP-625 chloride, SHP625 chloride, SHP 625 chloride, LUM001 chloride, Lopixibat chloride, Livmarli chlorideCas No. 228113-66-4

Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$263	In Stock	In Stock
5 mg	$496	In Stock	In Stock
10 mg	$745	In Stock	In Stock
25 mg	$1,330	In Stock	In Stock
50 mg	$1,880	In Stock	In Stock
100 mg	$2,630	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.99%

ee:99.5%

Appearance:Solid

Color:White

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COA CSFC ORP LCMS HNMR

Product Introduction

Bioactivity

Description	Maralixibat Chloride (LUM001 chloride), an apical, sodium-dependent, bile acid transport inhibitor, prevents enterohepatic bile acid recirculation.
Targets&IC50	Ileal sodium-dependent bile acid transporters:0.89 μM
In vivo	Maralixibat chloride can increase the level of sBA and reduce liver injury in cholestatic rats by partial bile duct ligation[1].
Synonyms	SHP-625 chloride, SHP625 chloride, SHP 625 chloride, LUM001 chloride, Lopixibat chloride, Livmarli chloride

Chemical Properties

Molecular Weight	710.41
Formula	C₄₀H₅₆ClN₃O₄S
Cas No.	228113-66-4
Smiles	[Cl-].CCCCC1(CCCC)CS(=O)(=O)c2ccc(cc2[C@H]([C@H]1O)c1ccc(OCc2ccc(C[N+]34CCN(CC3)CC4)cc2)cc1)N(C)C
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 150 mg/mL (211.15 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4076 mL	7.0382 mL	14.0764 mL	70.3819 mL
5 mM	0.2815 mL	1.4076 mL	2.8153 mL	14.0764 mL
10 mM	0.1408 mL	0.7038 mL	1.4076 mL	7.0382 mL
20 mM	0.0704 mL	0.3519 mL	0.7038 mL	3.5191 mL
50 mM	0.0282 mL	0.1408 mL	0.2815 mL	1.4076 mL
100 mM	0.0141 mL	0.0704 mL	0.1408 mL	0.7038 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc