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CCTA-1523

Name: CCTA-1523
Brand: TargetMol
SKU: T9587
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T9587Cas No. 1616271-41-0

CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.

CCTA-1523

🥰Excellent

Purity: 99.71%

Catalog No. T9587Cas No. 1616271-41-0

CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.

Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$202	In Stock
10 mg	$298	In Stock
25 mg	$476	In Stock
50 mg	$678	In Stock
100 mg	$912	In Stock
200 mg	$1,190	In Stock
1 mL x 10 mM (in DMSO)	$203	In Stock

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Bulk & Custom

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.71%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	CCTA-1523 is an efflux function of ABCG2 inhibitor. CCTA-1523 selectively reverses ABCG2-mediated MDR in cancer cells.
In vitro	CCTA-1523 (5μM) sensitized the ABCG2 overexpressing cancer cells and ABCG2 transfected cells to the substrate chemotherapeutic drugs[1].
In vivo	Co-administration of CCTA-1523 restored the in vivo antitumor activity of doxorubicin in ABCG2 overexpressing tumor xenografts[1].

Chemical Properties

Molecular Weight	340.2
Formula	C₁₆H₁₅Cl₂NO₃
Cas No.	1616271-41-0
Smiles	O(C)C=1C=C(C=CC1OC)C2=CC(NC(C(Cl)Cl)=O)=CC=C2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (146.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9394 mL	14.6972 mL	29.3945 mL	146.9724 mL
5 mM	0.5879 mL	2.9394 mL	5.8789 mL	29.3945 mL
10 mM	0.2939 mL	1.4697 mL	2.9394 mL	14.6972 mL
20 mM	0.1470 mL	0.7349 mL	1.4697 mL	7.3486 mL
50 mM	0.0588 mL	0.2939 mL	0.5879 mL	2.9394 mL
100 mM	0.0294 mL	0.1470 mL	0.2939 mL	1.4697 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc