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Trometamol

Name: Trometamol
Brand: TargetMol
SKU: T0961
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0961Cas No. 77-86-1

Alias Tromethamine, Tris

Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.

Trometamol

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Purity: 99.88%

Catalog No. T0961Alias Tromethamine, TrisCas No. 77-86-1

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
25 g	$29	-	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.88%

Appearance:Solid

Color:White

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	Trometamol (Tromethamine) is a proton acceptor used to treat acidemia. It inhibits both isoforms of cyclooxygenases (COX1 and COX2), thereby blocking the conversion of arachidonic acid to pro-inflammatory pro-prostaglandins.
In vivo	The drug is rapidly eliminated by the kidney; 75% or more appears in the urine after eight hours. Urinary excretion continues over a period of three days. The maximum daily dose is 15 mmol/kg for an adult. In large doses, trometamol may induce respiratory depression and hypoglycemia. [1]
Synonyms	Tromethamine, Tris

Chemical Properties

Molecular Weight	121.14
Formula	C₄H₁₁NO₃
Cas No.	77-86-1
Smiles	NC(CO)(CO)CO
Relative Density.	1.32. Temperature:20.4 °C.

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (495.29 mM), Sonication is recommended.

H2O: 198.1 mM, Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	8.2549 mL	41.2746 mL	82.5491 mL	412.7456 mL
5 mM	1.6510 mL	8.2549 mL	16.5098 mL	82.5491 mL
10 mM	0.8255 mL	4.1275 mL	8.2549 mL	41.2746 mL
20 mM	0.4127 mL	2.0637 mL	4.1275 mL	20.6373 mL
50 mM	0.1651 mL	0.8255 mL	1.6510 mL	8.2549 mL
100 mM	0.0825 mL	0.4127 mL	0.8255 mL	4.1275 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc