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CD155/PVR Protein, Human, Recombinant (hFc)

Catalog No. TMPY-00699
Synonyms: poliovirus receptor, NECL5, HVED, PVS, Necl-5, TAGE4, CD155

CD155/PVR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P15151-1.

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CD155/PVR Protein, Human, Recombinant (hFc)
Pack Size Availability Price/USD Quantity
100 μg In stock $ 249.00
200 μg 5 days $ 442.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Immobilized Recombinant Human TIGIT / VSTM3 Protein (His Tag) at 2 μg/mL (100 μl/well) can bind Recombinant Human CD155/PVR/NECL5 Protein (Fc Tag) , the EC50 is 10-30 ng/mL.

Description CD155/PVR Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 61.8 kDa and the accession number is P15151-1.
Species Human
Expression System HEK293 Cells
Tag C-hFc
Accession Number P15151-1
Synonyms poliovirus receptor, NECL5, HVED, PVS, Necl-5, TAGE4, CD155
Construction The extracellular domain (Met1-Asn343) of Human CD155 (P15151-1) was expressed with the C-terminal fused Fc region of Human IgG1.
Protein Purity > 95 % as determined by SDS-PAGE

Molecular Weight 61.8 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background CD155, commonly known as PVR (poliovirus receptor) and Necl-5 (nectin-like molecule-5), is a type I transmembrane single-span glycoprotein, and belongs to the nectins and nectin-like (Necl) subfamily. CD155 was originally identified based on its ability to mediate the cell attachment and entry of poliovirus (PV), an etiologic agent of the central nervous system disease poliomyelitis. The normal cellular function is in the establishment of intercellular adherens junctions between epithelial cells. CD155 may assist in an efficient humoral immune response generated within the intestinal immune system. It has been demonstrated that CD155 can be recognized and bond by DNAM-1 and CD96 which promote the adhesion, migration and NK-cell killing, and thus efficiently prime cell-mediated tumor-specific immunity.Cancer ImmunotherapyCo-inhibitory Immune Checkpoint TargetsImmune CheckpointImmune Checkpoint Detection: ELISA AntibodiesImmune Checkpoint Detection: FCM AntibodiesImmune Checkpoint Detection: ICC AntibodiesImmune Checkpoint Detection: IP AntibodiesImmune Checkpoint Detection: WB AntibodiesImmune Checkpoint ProteinsImmune Checkpoint TargetsImmunotherapyTargeted Therapy

References and Literature

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Keywords

CD155/PVR Protein, Human, Recombinant (hFc) TAGE 4 NECL-5 NECL 5 poliovirus receptor NECL5 HVED CD-155 PVS Necl-5 TAGE4 CD155 CD 155 TAGE-4 recombinant recombinant-proteins proteins protein

 

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