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Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.
Description | Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2. |
Targets&IC50 | TNF-α induction (RAW264.7 cells):5.9 nM (EC₅₀) |
In vitro | Neoseptin-3 is a synthetic small-molecule TLR4-MD-2 agonist that induces strong TNF-α expression in RAW264.7 cells (EC₅₀ = 5.9 ± 0.4 nM), comparable to LPS. Neoseptin-3 also activates TLR4 reporter systems and promotes NF-κB activation[1]. |
In vivo | In mice, intraperitoneal injection of Neoseptin-3 (2.5 mg/kg) significantly increases serum TNF-α levels, demonstrating in vivo TLR4 agonist activity[1]. |
Molecular Weight | 474.59 |
Formula | C29H34N2O4 |
Cas No. | 1622863-21-1 |
Smiles | C(N[C@@H](CCC1=CC=CC=C1)C(OC(C)(C)C)=O)(=O)C2=CC(CCC3=CC=C(O)C=C3)=C(N)C=C2 |
Relative Density. | 1.174 g/cm3 (Predicted) |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (168.57 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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