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Neoseptin-3

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Catalog No. T16284Cas No. 1622863-21-1

Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.

Neoseptin-3

Neoseptin-3

🥰Excellent
Catalog No. T16284Cas No. 1622863-21-1
Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.
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Product Introduction

Bioactivity
Description
Neoseptin-3 is a novel small molecule agonist of mouse mTLR4/MD2 with EC50=18.5 μM that does not activate human TLR4/MD2.
Targets&IC50
TNF-α induction (RAW264.7 cells):5.9 nM (EC₅₀)
In vitro
Neoseptin-3 is a synthetic small-molecule TLR4-MD-2 agonist that induces strong TNF-α expression in RAW264.7 cells (EC₅₀ = 5.9 ± 0.4 nM), comparable to LPS. Neoseptin-3 also activates TLR4 reporter systems and promotes NF-κB activation[1].
In vivo
In mice, intraperitoneal injection of Neoseptin-3 (2.5 mg/kg) significantly increases serum TNF-α levels, demonstrating in vivo TLR4 agonist activity[1].
Chemical Properties
Molecular Weight474.59
FormulaC29H34N2O4
Cas No.1622863-21-1
SmilesC(N[C@@H](CCC1=CC=CC=C1)C(OC(C)(C)C)=O)(=O)C2=CC(CCC3=CC=C(O)C=C3)=C(N)C=C2
Relative Density.1.174 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice./Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (168.57 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.1071 mL10.5354 mL21.0708 mL105.3541 mL
5 mM0.4214 mL2.1071 mL4.2142 mL21.0708 mL
10 mM0.2107 mL1.0535 mL2.1071 mL10.5354 mL
20 mM0.1054 mL0.5268 mL1.0535 mL5.2677 mL
50 mM0.0421 mL0.2107 mL0.4214 mL2.1071 mL
100 mM0.0211 mL0.1054 mL0.2107 mL1.0535 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
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