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SR12418
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Catalog No. T63206Cas No. 1801185-08-9
Alias SR-12418, SR 12418
SR12418 is a specific synthetic ligand for REV-ERB, demonstrating binding affinity for both REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. SR12418 inhibits IL-17A expression in EL4 cells and suppresses TH17 cell differentiation, making it suitable for studies on experimental autoimmune encephalomyelitis (EAE) and colitis.
SR12418
😃Good
Purity: 99.96%
Catalog No. T63206Alias SR-12418, SR 12418Cas No. 1801185-08-9
SR12418 is a specific synthetic ligand for REV-ERB, demonstrating binding affinity for both REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. SR12418 inhibits IL-17A expression in EL4 cells and suppresses TH17 cell differentiation, making it suitable for studies on experimental autoimmune encephalomyelitis (EAE) and colitis.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $71 | - | In Stock | |
| 2 mg | $98 | - | In Stock | |
| 5 mg | $172 | - | In Stock | |
| 10 mg | $289 | - | In Stock | |
| 25 mg | $579 | - | In Stock | |
| 1 mL x 10 mM (in DMSO) | $183 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.96%
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Product Introduction
Bioactivity
Chemical Properties
| Description | SR12418 is a specific synthetic ligand for REV-ERB, demonstrating binding affinity for both REV-ERBα (IC50 = 68 nM) and REV-ERBβ (IC50 = 119 nM) in TR-FRET assays. SR12418 inhibits IL-17A expression in EL4 cells and suppresses TH17 cell differentiation, making it suitable for studies on experimental autoimmune encephalomyelitis (EAE) and colitis. |
| Targets&IC50 | REV-ERBβ:119 nM, REV-ERBα:68 nM |
| In vitro | SR12418 at a concentration of 5 μM for 96 hours can inhibit the growth of TH17 cells [1]. Under TH17 polarization induction conditions, SR12418 (5 and 10 μM, 4 days) can suppress cell differentiation [1]. |
| In vivo | SR12418 (50 mg/kg, intraperitoneal injection, twice daily) can inhibit the onset and disease severity of experimental autoimmune encephalomyelitis (EAE) [1]. Starting from day 18 post-immunization, SR12418 (50 mg/kg, intraperitoneal injection, twice daily) demonstrates therapeutic effects in the intervention study of relapsing-remitting experimental autoimmune encephalomyelitis [1]. |
| Synonyms | SR-12418, SR 12418 |
| Molecular Weight | 483.57 |
| Formula | C31H30FNO3 |
| Cas No. | 1801185-08-9 |
| Smiles | C(=O)(N1[C@H](COC2=CC=C(OC(C)(C)C)C=C2)CC=3C(C1)=CC=C(F)C3)C=4C5=C(C=CC4)C=CC=C5 |
| Color | White |
| Appearance | Solid |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (165.44 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
| In Vivo Formulation | 10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (6.82 mM), Sonication is recommeded. Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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