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Brompheniramine maleate

Name: Brompheniramine maleate
Brand: TargetMol
SKU: T0205
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T0205Cas No. 980-71-2

Alias Rolabromophen, Dimotane, Dimetane, Brompheniramine hydrogen maleate

Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.

Brompheniramine maleate

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Purity: 99.80%

Catalog No. T0205Alias Rolabromophen, Dimotane, Dimetane, Brompheniramine hydrogen maleateCas No. 980-71-2

Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$29	In Stock	In Stock
50 mg	$37	In Stock	In Stock
100 mg	$48	In Stock	In Stock
200 mg	$89	In Stock	In Stock
500 mg	$152	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$29	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.80%

Appearance:Solid

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Brompheniramine maleate AI Summary

Brompheniramine maleate exhibits a broad spectrum of bioactivities and is known for its antiplasmodial activity against various strains of Plasmodium falciparum, demonstrating different IC50 values ranging from 794.3 nM to 1584.9 nM. It also shows inhibitory activity against multiple enzymes, including AmpC Beta-Lactamase and T. brucei phosphofructokinase, with potencies ranging from 354.8 nM to 15848.9 nM. Moreover, Brompheniramine maleate inhibits chronic active B-cell receptor signaling, Hepatitis C Virus, and human tyrosyl-DNA phosphodiesterase 1 among others, with potencies from 82.8 nM to 18,356.4 nM. As part of the Drug Induced Liver Injury Prediction System (DILIps) validation dataset, Brompheniramine maleate has been noted to be negative for Drug Induced Liver Injury based on Pfizer data. It also demonstrates substantial inhibition in OATP1B3 and OATP1B1-transfected CHO cells (90.7% and 88.52% inhibition respectively at 10 µM), but shows no significant inhibitory activity against human BSEP, MRP2, MRP3, and MRP4, with IC50 values greater than 133,000 nM. In the context of antiviral activity, Brompheniramine maleate shows limited inhibition of cell viability in Vero E6 cells infected with SARS-CoV-2 (strain BavPat1), exhibiting an inhibition index of 0.3833. Its role in inhibiting SARS-CoV-2-induced cytotoxicity in VERO-6 and Caco-2 cells is minimal, showing -0.02% and -2.74% inhibition at 10 µM concentration after 48 hours. Additionally, it exhibits 4.102% inhibition of the SARS-CoV-2 3CL-Pro protease at 20 µM, suggesting some potential inhibitory activity against this protease..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Brompheniramine maleate (Dimotane) is an antagonist against histamine H1 receptors.
Targets&IC50	H1 receptor:6.06 nM (Kd)
Synonyms	Rolabromophen, Dimotane, Dimetane, Brompheniramine hydrogen maleate

Chemical Properties

Molecular Weight	435.31
Formula	C₁₆H₁₉BrN₂·C₄H₄O₄
Cas No.	980-71-2
Smiles	OC(=O)/C=C\C(=O)O.CN(C)CCC(c1ccc(Br)cc1)c1ccccn1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 42 mg/mL (96.48 mM), Sonication is recommended.

Ethanol: 15 mg/mL (34.46 mM), Sonication is recommended.

DMSO: 81 mg/mL (186.07 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (7.58 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

Ethanol/H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2972 mL	11.4861 mL	22.9721 mL	114.8607 mL
5 mM	0.4594 mL	2.2972 mL	4.5944 mL	22.9721 mL
10 mM	0.2297 mL	1.1486 mL	2.2972 mL	11.4861 mL
20 mM	0.1149 mL	0.5743 mL	1.1486 mL	5.7430 mL

H2O/DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0459 mL	0.2297 mL	0.4594 mL	2.2972 mL

DMSO

	1mg	5mg	10mg	50mg
100 mM	0.0230 mL	0.1149 mL	0.2297 mL	1.1486 mL

Calculator

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc