Shopping Cart

Your shopping cart is currently empty

Eupalinolide A

Name: Eupalinolide A
Brand: TargetMol
SKU: T5826
Price: 66 USD
Availability: InStock
Rating: 5 (10 reviews)

Copy Product Info

🥰Excellent

Catalog No. T5826Cas No. 877822-40-7

Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.

Eupalinolide A

Copy Product Info

🥰Excellent

Purity: 99.22%

Catalog No. T5826Cas No. 877822-40-7

Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$66	In Stock	In Stock
10 mg	$105	In Stock	In Stock
25 mg	$222	In Stock	In Stock
50 mg	$328	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$83	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.22%

Color:White

Resource Download

COA

Product Introduction

Bioactivity

Description

Eupalinolide B is a natural product ,and demonstrates potent cytotoxicity against A-549, BGC-823, SMMC-7721, and HL-60 tumour cell lines.

In vitro

Eupalinolide B and A (EB and EA) from E. lindleyanum, and describe their actions as HSP-inducers.?EA and EB both induced the expression of HSP70 in cells at concentrations that did not significantly affect cell viability.?Treatment of cells with EA or EB activated heat shock factor 1 (HSF1), while the artificial suppression of HSF1 expression diminished the EA- or EB-mediated induction of HSP70 expression.?Furthermore, EB inhibited the interaction between HSF1 and HSP90, which is known to inhibit the activity of HSF1.?Suggest that EA and EB induce the expression of HSP70 via the activation of HSF1 by inhibiting the interaction between HSF1 and HSP90.?EA and EB both induced the expression of HSP70 synergistically with other stressors.?Furthermore, pre-treatment of cells with EA or EB suppressed melanin production and stressor-induced apoptosis.?These effects were suppressed by the artificial suppression of HSP70 expression.?In vivo, the percutaneous administration of EB induced the expression of HSP70 and suppressed UVB radiation-induced damage, inflammatory responses and melanin production in the skin.[1]

Chemical Properties

Molecular Weight	462.49
Formula	C₂₄H₃₀O₉
Cas No.	877822-40-7
Smiles	[H][C@]12OC(=O)C(=C)[C@]1([H])[C@@H](C\C(COC(C)=O)=C/C[C@H](OC(C)=O)\C(C)=C/2)OC(=O)C(\C)=C\CO
Relative Density.	1.24 g/cm3 at 20℃

Storage & Solubility Information

Storage

keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 240 mg/mL (518.93 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (4.32 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1622 mL	10.8110 mL	21.6221 mL	108.1104 mL
5 mM	0.4324 mL	2.1622 mL	4.3244 mL	21.6221 mL
10 mM	0.2162 mL	1.0811 mL	2.1622 mL	10.8110 mL
20 mM	0.1081 mL	0.5406 mL	1.0811 mL	5.4055 mL
50 mM	0.0432 mL	0.2162 mL	0.4324 mL	2.1622 mL
100 mM	0.0216 mL	0.1081 mL	0.2162 mL	1.0811 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc